No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
|
1. Apply sex-specific ruleNone |
- |
2. Check conditionsNone |
|
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
- |
4. Check minimum number of eventsNone |
- |
5. Include endpointsNone |
- |
6. Filter based on genotype QC (FinnGen only)None |
- |
Control definitions (FinnGen only)
Control exclude
G6_AD_WIDE, F5_DEMENTIA, F5_DEMENTIA_U, F5_PSYCH, NEURODIS, MEMLOSS, TRAUMBRAIN_NONCONCUS
Extra metadata
First used in FinnGen datafreeze
DF2
Similar endpoints
↥List of similar endpoints to
Alzheimer’s disease (undefined)
based on the number of shared cases.
Similar with more cases:
- Alzheimer’s disease (undefined)
- Dementia in Alzheimer disease
- Alzheimer disease
- Alzheimer disease
- Other degenerative diseases of the nervous system
Similar with less cases:
Case counts by codes
↥FinnGen case counts by registry codes:
No upset plot: script not run.
No upset table: script not run.
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 12062 | 7792 | 4086 |
| Only index persons | 8572 | 5763 | 2809 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.19 | 0.22 | 0.11 |
| Only index persons | 0.18 | 0.21 | 0.11 |
| Median age at first event (years) | |||
| Whole population | 82.15 | 82.98 | 80.69 |
| Only index persons | 82.66 | 83.38 | 81.18 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 455 | 189 | 266 |
| Unadjusted period prevalence (%) | 0.11 | 0.07 | 0.13 |
| Median age at first event (years) | 80.39 | 82.30 | 79.03 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint AD_U_EXMORE and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| AD_U_EXMORE | 2.456 [2.2, 2.74] | < 0.001 |
| Birth year | 0.993 [0.99, 1.0] | 0.109 |
During the follow-up period (1.1.1998 — 31.12.2019), 6337 out of 7115 females with AD_U_EXMORE died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| AD_U_EXMORE | 3.053 [2.55, 3.65] | < 0.001 |
| Birth year | 0.987 [0.98, 1.0] | 0.006 |
During the follow-up period (1.1.1998 — 31.12.2019), 3338 out of 3652 males with AD_U_EXMORE died.
Mortality risk
Mortality risk for people of age
years, who have AD_U_EXMORE.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.289% | 0.508% |
| 5 | 1.414% | 3.453% |
| 10 | 3.811% | 8.089% |
| 15 | 7.001% | 15.732% |
| 20 | 11.882% | 25.234% |
Relationships between endpoints
↥Index endpoint: AD_U_EXMORE – Alzheimer’s disease (undefined)
GWS hits: 3
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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