No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
3124 |
4. Check minimum number of eventsNone |
3124 |
5. Include endpointsNone |
3124 |
6. Filter based on genotype QC (FinnGen only) |
3013 |
Control definitions (FinnGen only)
Control exclude
F5_DEMENTIA, G6_ALZHEIMER, G6_AD_WIDE
Extra metadata
First used in FinnGen datafreeze
DF2
Similar endpoints
↥List of similar endpoints to
Memory loss
based on the number of shared cases.
Similar with more cases:
- Other symptoms and signs involving cognitive functions and awareness
- Symptoms and signs involving cognition, perception, emotional state and behaviour
- Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 26901 | 15057 | 11756 |
| Only index persons | 25069 | 14240 | 10829 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.39 | 0.43 | 0.33 |
| Only index persons | 0.48 | 0.52 | 0.41 |
| Median age at first event (years) | |||
| Whole population | 71.05 | 72.62 | 69.03 |
| Only index persons | 70.85 | 72.43 | 68.77 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 3013 | 1588 | 1425 |
| Unadjusted period prevalence (%) | 0.67 | 0.62 | 0.72 |
| Median age at first event (years) | 68.51 | 67.28 | 69.89 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint MEMLOSS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| MEMLOSS | 1.425 [1.29, 1.57] | < 0.001 |
| Birth year | 0.998 [0.99, 1.01] | 0.601 |
During the follow-up period (1.1.1998 — 31.12.2019), 4259 out of 13459 females with MEMLOSS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| MEMLOSS | 1.542 [1.38, 1.72] | < 0.001 |
| Birth year | 0.986 [0.98, 1.0] | 0.003 |
During the follow-up period (1.1.1998 — 31.12.2019), 3776 out of 10590 males with MEMLOSS died.
Mortality risk
Mortality risk for people of age
years, who have MEMLOSS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.157% | 0.285% |
| 5 | 0.858% | 1.859% |
| 10 | 2.264% | 4.693% |
| 15 | 4.217% | 8.456% |
| 20 | 7.286% | 13.969% |
Relationships between endpoints
↥Index endpoint: MEMLOSS – Memory loss
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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