Alzheimer's disease: A progressive, neurodegenerative disease characterized by loss of function and death of nerve cells in several areas of the brain leading to loss of cognitive function such as memory and language.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
4 out of 7 registries used, show all original rules. |
17523 |
4. Check minimum number of events
Min. number of events
3
|
17523 |
5. Include endpoints |
17523 |
6. Filter based on genotype QC (FinnGen only) |
16902 |
Control definitions (FinnGen only)
Control exclude
G6_ALZHEIMER
Extra metadata
First used in FinnGen datafreeze
DF3
Alzheimer’s disease, wide definition
based on the number of shared cases.
Similar with more cases:
Similar with less cases:
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 296681 | 184829 | 109969 |
| Only index persons | 255430 | 161059 | 94371 |
| Unadjusted period prevalence (%) | |||
| Whole population | 4.45 | 5.29 | 3.07 |
| Only index persons | 5.06 | 5.92 | 3.60 |
| Median age at first event (years) | |||
| Whole population | 80.87 | 81.69 | 79.54 |
| Only index persons | 81.07 | 81.88 | 79.69 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 16902 | 7607 | 9295 |
| Unadjusted period prevalence (%) | 3.91 | 2.99 | 4.67 |
| Median age at first event (years) | 79.10 | 79.21 | 79.01 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint G6_AD_WIDE and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| G6_AD_WIDE | 2.209 [2.02, 2.41] | < 0.001 |
| Birth year | 0.987 [0.98, 0.99] | 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 94565 out of 156946 females with G6_AD_WIDE died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| G6_AD_WIDE | 2.25 [2.01, 2.52] | < 0.001 |
| Birth year | 0.984 [0.98, 0.99] | < 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 57338 out of 92451 males with G6_AD_WIDE died.
Mortality risk
Mortality risk for people of age
years, who have G6_AD_WIDE.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.116% | 0.358% |
| 5 | 0.728% | 2.175% |
| 10 | 1.889% | 5.058% |
| 15 | 3.633% | 9.382% |
| 20 | 6.035% | 15.046% |
Relationships between endpoints
↥Index endpoint: G6_AD_WIDE – Alzheimer’s disease, wide definition
GWS hits: 21
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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