Alzheimer's disease: A progressive, neurodegenerative disease characterized by loss of function and death of nerve cells in several areas of the brain leading to loss of cognitive function such as memory and language.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
6971 |
4. Check minimum number of eventsNone |
6971 |
5. Include endpointsNone |
6971 |
6. Filter based on genotype QC (FinnGen only) |
6741 |
Control definitions (FinnGen only)
Control exclude
F5_ORGANIC
Extra metadata
Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF3
Similar endpoints
↥List of similar endpoints to
Dementia in Alzheimer disease
based on the number of shared cases.
Similar with more cases:
- Alzheimer’s disease, wide definition
- Alzheimer’s disease, wide definition
- Any dementia
- Any dementia
- Dementia
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 128670 | 81960 | 45831 |
| Only index persons | 110175 | 71387 | 38788 |
| Unadjusted period prevalence (%) | |||
| Whole population | 1.96 | 2.35 | 1.28 |
| Only index persons | 2.22 | 2.62 | 1.48 |
| Median age at first event (years) | |||
| Whole population | 82.30 | 83.00 | 81.09 |
| Only index persons | 82.63 | 83.30 | 81.39 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 6741 | 3063 | 3678 |
| Unadjusted period prevalence (%) | 1.55 | 1.20 | 1.85 |
| Median age at first event (years) | 80.49 | 80.39 | 80.56 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint F5_ALZHDEMENT and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| F5_ALZHDEMENT | 2.398 [2.17, 2.65] | < 0.001 |
| Birth year | 0.991 [0.98, 1.0] | 0.03 |
During the follow-up period (1.1.1998 — 31.12.2019), 48483 out of 70483 females with F5_ALZHDEMENT died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| F5_ALZHDEMENT | 2.838 [2.47, 3.27] | < 0.001 |
| Birth year | 0.988 [0.98, 1.0] | 0.006 |
During the follow-up period (1.1.1998 — 31.12.2019), 27543 out of 38138 males with F5_ALZHDEMENT died.
Mortality risk
Mortality risk for people of age
years, who have F5_ALZHDEMENT.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.185% | 0.525% |
| 5 | 1.168% | 2.954% |
| 10 | 3.006% | 7.145% |
| 15 | 5.373% | 13.483% |
| 20 | 9.032% | 22.437% |
Relationships between endpoints
↥Index endpoint: F5_ALZHDEMENT – Dementia in Alzheimer disease
GWS hits: 8
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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