No definition available.
severe traumatic brain injury, does not include concussion
EFO MESH Endpoint Browser PheWeb
TRAUMBRAIN_NONCONCUS
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
8586 |
4. Check minimum number of eventsNone |
8586 |
5. Include endpointsNone |
8586 |
6. Filter based on genotype QC (FinnGen only) |
8304 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
First used in FinnGen datafreeze
DF2
Similar endpoints
↥List of similar endpoints to
severe traumatic brain injury, does not include concussion
based on the number of shared cases.
Similar with more cases:
- Intracranial trauma
- Neurological diseases
- Injury, poisoning and certain other consequences of external causes
- Any event in hilmo or specialist outpatient
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 106054 | 35930 | 68952 |
| Only index persons | 82363 | 29663 | 52700 |
| Unadjusted period prevalence (%) | |||
| Whole population | 1.61 | 1.03 | 1.93 |
| Only index persons | 1.68 | 1.09 | 2.01 |
| Median age at first event (years) | |||
| Whole population | 62.24 | 70.94 | 57.70 |
| Only index persons | 62.10 | 70.37 | 57.44 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 8304 | 2840 | 5464 |
| Unadjusted period prevalence (%) | 2.19 | 1.12 | 2.74 |
| Median age at first event (years) | 64.80 | 63.51 | 65.47 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint TRAUMBRAIN_NONCONCUS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| TRAUMBRAIN_NONCONCUS | 1.917 [1.72, 2.13] | < 0.001 |
| Birth year | 0.998 [0.99, 1.01] | 0.628 |
During the follow-up period (1.1.1998 — 31.12.2019), 8951 out of 22982 females with TRAUMBRAIN_NONCONCUS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| TRAUMBRAIN_NONCONCUS | 2.315 [2.07, 2.59] | < 0.001 |
| Birth year | 0.985 [0.98, 0.99] | 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 15130 out of 40586 males with TRAUMBRAIN_NONCONCUS died.
Mortality risk
Mortality risk for people of age
years, who have TRAUMBRAIN_NONCONCUS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.183% | 0.387% |
| 5 | 1.187% | 2.259% |
| 10 | 3.061% | 5.941% |
| 15 | 5.892% | 10.83% |
| 20 | 10.32% | 18.067% |
Relationships between endpoints
↥Index endpoint: TRAUMBRAIN_NONCONCUS – severe traumatic brain injury, does not include concussion
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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