No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
|
1. Apply sex-specific ruleNone |
- |
2. Check conditionsNone |
|
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
- |
4. Check minimum number of eventsNone |
- |
5. Include endpointsNone |
- |
6. Filter based on genotype QC (FinnGen only)None |
- |
Control definitions (FinnGen only)
Control exclude
G6_AD_WIDE, F5_DEMENTIA, F5_DEMENTIA_U, F5_PSYCH, NEURODIS, MEMLOSS, TRAUMBRAIN_NONCONCUS
Extra metadata
First used in FinnGen datafreeze
DF2
Similar endpoints
↥List of similar endpoints to
Alzheimer’s disease (Late onset)
based on the number of shared cases.
Similar with more cases:
- Alzheimer’s disease (Late onset)
- Alzheimer’s disease, wide definition
- Alzheimer’s disease, wide definition
- Any dementia
- Any dementia
Similar with less cases:
Case counts by codes
↥FinnGen case counts by registry codes:
No upset plot: script not run.
No upset table: script not run.
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 155025 | 100212 | 53777 |
| Only index persons | 132407 | 86940 | 45467 |
| Unadjusted period prevalence (%) | |||
| Whole population | 2.38 | 2.87 | 1.50 |
| Only index persons | 2.69 | 3.20 | 1.74 |
| Median age at first event (years) | |||
| Whole population | 82.51 | 83.17 | 81.33 |
| Only index persons | 82.80 | 83.44 | 81.58 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 8241 | 3864 | 4377 |
| Unadjusted period prevalence (%) | 1.88 | 1.52 | 2.20 |
| Median age at first event (years) | 80.52 | 80.51 | 80.53 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint AD_LO_EXMORE and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| AD_LO_EXMORE | 2.157 [1.96, 2.37] | < 0.001 |
| Birth year | 0.991 [0.98, 1.0] | 0.03 |
During the follow-up period (1.1.1998 — 31.12.2019), 51753 out of 77066 females with AD_LO_EXMORE died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| AD_LO_EXMORE | 2.456 [2.15, 2.8] | < 0.001 |
| Birth year | 0.984 [0.97, 0.99] | < 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 28916 out of 40995 males with AD_LO_EXMORE died.
Mortality risk
Mortality risk for people of age
years, who have AD_LO_EXMORE.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.192% | 0.398% |
| 5 | 1.076% | 2.257% |
| 10 | 2.645% | 5.951% |
| 15 | 4.815% | 10.915% |
| 20 | 8.022% | 18.077% |
Relationships between endpoints
↥Index endpoint: AD_LO_EXMORE – Alzheimer’s disease (Late onset)
GWS hits: 10
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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