No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
586 |
4. Check minimum number of eventsNone |
586 |
5. Include endpointsNone |
586 |
6. Filter based on genotype QC (FinnGen only) |
570 |
Control definitions (FinnGen only)
Control exclude
F5_DEMENTIA, G6_ALZHEIMER, G6_AD_WIDE
Extra metadata
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
F01
Name in latin
Dementia e multis infarctibus
Similar endpoints
↥List of similar endpoints to
Vascular dementia (multiple infarctions)
based on the number of shared cases.
Similar with more cases:
- Vascular dementia
- Dementia
- Dementia, including avohilmo
- Organic, including symptomatic, mental disorders
- Psychiatric diseases
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 17740 | 8997 | 8189 |
| Only index persons | 5236 | 2717 | 2519 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.25 | 0.26 | 0.23 |
| Only index persons | 0.10 | 0.10 | 0.10 |
| Median age at first event (years) | |||
| Whole population | 79.25 | 80.73 | 77.74 |
| Only index persons | 80.26 | 82.38 | 77.98 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 570 | 165 | 405 |
| Unadjusted period prevalence (%) | 0.16 | 0.06 | 0.20 |
| Median age at first event (years) | 76.53 | 78.09 | 75.90 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint VD_MI and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| VD_MI | 2.991 [2.64, 3.39] | < 0.001 |
| Birth year | 1.0 [0.99, 1.01] | 0.916 |
During the follow-up period (1.1.1998 — 31.12.2019), 3138 out of 3584 females with VD_MI died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| VD_MI | 3.558 [2.97, 4.26] | < 0.001 |
| Birth year | 0.986 [0.98, 1.0] | 0.003 |
During the follow-up period (1.1.1998 — 31.12.2019), 2806 out of 3330 males with VD_MI died.
Mortality risk
Mortality risk for people of age
years, who have VD_MI.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.241% | 0.492% |
| 5 | 1.79% | 3.705% |
| 10 | 4.924% | 9.421% |
| 15 | 9.633% | 17.903% |
| 20 | 16.907% | 28.507% |
Relationships between endpoints
↥Index endpoint: VD_MI – Vascular dementia (multiple infarctions)
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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