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Senile degeneration of the brain, not elsewhere classified

DOID EFO Endpoint Browser PheWeb

G6_DEGENSEN

neurodegenerative disease: A disorder of the central nervous system characterized by gradual and progressive loss of neural tissue and neurologic function.

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Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — G31.1
  • Hospital discharge: ICD-9 — 3312
  • Hospital discharge: ICD-8 — 34792
  • Cause of death: ICD-10 — G31.1
  • Cause of death: ICD-9 — 3312
  • Cause of death: ICD-8 — 34792

2 out of 7 registries used, show all original rules.

139

4. Check minimum number of events

None

139

5. Include endpoints

None

139

6. Filter based on genotype QC (FinnGen only)

133

Control definitions (FinnGen only)

Control exclude G6_NEURODEG

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF6
Parent code in ICD-10 G31
Name in latin Degeneratio cerebri senilis non alibi classificata

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 3797 1926 1743
Only index persons 1467 804 663
Unadjusted period prevalence (%)
Whole population 0.05 0.06 0.05
Only index persons 0.03 0.03 0.03
Median age at first event (years)
Whole population 75.25 76.87 73.64
Only index persons 76.36 78.22 74.12

-FinnGen-

Key figures

All Female Male
Number of individuals 133 45 88
Unadjusted period prevalence (%) 0.04 0.02 0.04
Median age at first event (years) 73.53 74.83 72.87

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

Mortality – FinRegistry

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Association

Association between endpoint G6_DEGENSEN and mortality.

Females

Parameter HR [95% CI] p-value
G6_DEGENSEN 2.462 [2.03, 2.98] < 0.001
Birth year 0.992 [0.98, 1.0] 0.078

During the follow-up period (1.1.1998 — 31.12.2019), 693 out of 897 females with G6_DEGENSEN died.

Males

Parameter HR [95% CI] p-value
G6_DEGENSEN 2.829 [2.17, 3.68] < 0.001
Birth year 0.989 [0.98, 1.0] 0.015

During the follow-up period (1.1.1998 — 31.12.2019), 543 out of 705 males with G6_DEGENSEN died.

Mortality risk

Mortality risk for people of age

years, who have G6_DEGENSEN.

N-year risk Females Males
1 0.186% 0.6%
5 1.292% 3.795%
10 3.155% 8.592%
15 6.112% 15.646%
20 10.464% 25.722%

Relationships between endpoints

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Index endpoint: G6_DEGENSEN – Senile degeneration of the brain, not elsewhere classified

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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