alcoholic neuropathy: A condition where damage to the peripheral nervous system (including the peripheral elements of the autonomic nervous system) is associated with chronic ingestion of alcoholic beverages. The disorder may be caused by a direct effect of alcohol, an associated nutritional deficiency, or a combination of factors. Clinical manifestations include variable degrees of weakness; ATROPHY; PARESTHESIAS; pain; loss of reflexes; sensory loss; diaphoresis; and postural hypotension. (From Arch Neurol 1995;52(1):45-51; Adams et al., Principles of Neurology, 6th ed, p1146)
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
303 |
4. Check minimum number of eventsNone |
303 |
5. Include endpointsNone |
303 |
6. Filter based on genotype QC (FinnGen only) |
293 |
Control definitions (FinnGen only)
Control exclude
G6_POLYNEU
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
G62
Name in latin
Polyneuropathia alcoholica
Similar endpoints
↥List of similar endpoints to
Alcohol induced polyneuropathy
based on the number of shared cases.
Similar with more cases:
- Alcohol induced polyneuropathy
- Polyneuropathies and other disorders of the peripheral nervous system
- Alcohol use disorder, Swedish definition
- Alcohol related diseases, tilastokeskus definition
- Alcohol related diseases and deaths, all endpoints
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 4609 | 835 | 3665 |
| Only index persons | 3095 | 628 | 2467 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.09 | 0.02 | 0.10 |
| Only index persons | 0.08 | 0.02 | 0.09 |
| Median age at first event (years) | |||
| Whole population | 57.12 | 56.02 | 57.32 |
| Only index persons | 57.57 | 57.05 | 57.70 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 293 | 57 | 236 |
| Unadjusted period prevalence (%) | 0.10 | 0.02 | 0.12 |
| Median age at first event (years) | 58.19 | 55.23 | 58.91 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint G6_ALCOPOLY and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| G6_ALCOPOLY | 6.471 [5.09, 8.24] | < 0.001 |
| Birth year | 0.995 [0.99, 1.0] | 0.275 |
During the follow-up period (1.1.1998 — 31.12.2019), 255 out of 596 females with G6_ALCOPOLY died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| G6_ALCOPOLY | 5.295 [4.65, 6.04] | < 0.001 |
| Birth year | 0.984 [0.97, 0.99] | 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 1346 out of 2491 males with G6_ALCOPOLY died.
Mortality risk
Mortality risk for people of age
years, who have G6_ALCOPOLY.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.432% | 0.871% |
| 5 | 3.556% | 5.907% |
| 10 | 9.79% | 13.436% |
| 15 | 17.855% | 24.306% |
| 20 | 29.641% | 37.061% |
Relationships between endpoints
↥Index endpoint: G6_ALCOPOLY – Alcohol induced polyneuropathy
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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