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Other diseases of stomach and duodenum

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K11_OTHDISSTOMDUOD

Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — K31
  • Hospital discharge: ICD-9 — 536|537
  • Hospital discharge: ICD-8 — 536|537
  • Hospital discharge: excluded ICD-9 — 5368A
  • Hospital discharge: excluded ICD-8 — 5361
  • Cause of death: ICD-10 — K31
  • Cause of death: ICD-9 — 536|537
  • Cause of death: ICD-8 — 536|537
  • Cause of death: excluded ICD-9 — 5368A
  • Cause of death: excluded ICD-8 — 5361

2 out of 7 registries used, show all original rules.

2236

4. Check minimum number of events

None

2236

5. Include endpoints

None

2236

6. Filter based on genotype QC (FinnGen only)

2162

Control definitions (FinnGen only)

Control exclude K11_OESSTODUO

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 K20-K31
Name in latin Alii morbi ventriculi et duodeni

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 20470 10889 9300
Only index persons 14982 8309 6673
Unadjusted period prevalence (%)
Whole population 0.29 0.31 0.26
Only index persons 0.28 0.31 0.25
Median age at first event (years)
Whole population 59.13 60.72 57.22
Only index persons 56.40 57.84 54.60

-FinnGen-

Key figures

All Female Male
Number of individuals 2162 1184 978
Unadjusted period prevalence (%) 0.48 0.47 0.49
Median age at first event (years) 59.31 57.63 61.35

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Association

Association between endpoint K11_OTHDISSTOMDUOD and mortality.

Females

Parameter HR [95% CI] p-value
K11_OTHDISSTOMDUOD 2.045 [1.81, 2.31] < 0.001
Birth year 0.991 [0.98, 1.0] 0.04

During the follow-up period (1.1.1998 — 31.12.2019), 1607 out of 5149 females with K11_OTHDISSTOMDUOD died.

Males

Parameter HR [95% CI] p-value
K11_OTHDISSTOMDUOD 2.362 [2.04, 2.73] < 0.001
Birth year 0.989 [0.98, 1.0] 0.013

During the follow-up period (1.1.1998 — 31.12.2019), 1669 out of 4143 males with K11_OTHDISSTOMDUOD died.

Mortality risk

Mortality risk for people of age

years, who have K11_OTHDISSTOMDUOD.

N-year risk Females Males
1 0.199% 0.411%
5 0.989% 2.711%
10 2.536% 6.911%
15 4.999% 13.211%
20 8.618% 22.63%

Relationships between endpoints

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Index endpoint: K11_OTHDISSTOMDUOD – Other diseases of stomach and duodenum

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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