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Oesophageal obstruction

DOID EFO Endpoint Browser PheWeb

K11_OESOBST

Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — K22.2
  • Hospital discharge: ICD-9 — 5303
  • Hospital discharge: ICD-8 — 5303
  • Cause of death: ICD-10 — K22.2
  • Cause of death: ICD-9 — 5303
  • Cause of death: ICD-8 — 5303

2 out of 7 registries used, show all original rules.

1187

4. Check minimum number of events

None

1187

5. Include endpoints

None

1187

6. Filter based on genotype QC (FinnGen only)

1147

Control definitions (FinnGen only)

Control exclude K11_OESSTODUO

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 K22
Name in latin Obstructio oesophagi

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 10378 4277 5966
Only index persons 7927 3308 4619
Unadjusted period prevalence (%)
Whole population 0.15 0.12 0.17
Only index persons 0.15 0.12 0.18
Median age at first event (years)
Whole population 67.37 70.35 65.19
Only index persons 66.11 68.96 64.07

-FinnGen-

Key figures

All Female Male
Number of individuals 1147 445 702
Unadjusted period prevalence (%) 0.28 0.17 0.35
Median age at first event (years) 66.01 64.46 66.99

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Association

Association between endpoint K11_OESOBST and mortality.

Females

Parameter HR [95% CI] p-value
K11_OESOBST 2.105 [1.86, 2.38] < 0.001
Birth year 0.991 [0.98, 1.0] 0.039

During the follow-up period (1.1.1998 — 31.12.2019), 1435 out of 3155 females with K11_OESOBST died.

Males

Parameter HR [95% CI] p-value
K11_OESOBST 2.364 [2.09, 2.68] < 0.001
Birth year 0.991 [0.98, 1.0] 0.041

During the follow-up period (1.1.1998 — 31.12.2019), 2067 out of 4493 males with K11_OESOBST died.

Mortality risk

Mortality risk for people of age

years, who have K11_OESOBST.

N-year risk Females Males
1 0.172% 0.425%
5 1.071% 2.722%
10 2.621% 7.782%
15 5.238% 14.343%
20 9.321% 23.381%

Relationships between endpoints

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Index endpoint: K11_OESOBST – Oesophageal obstruction

GWS hits: 1

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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