Disorders of oesophagus in diseases classified elsewhere

K11_DISOESINOTH

esophageal disease: A non-neoplastic or neoplastic disorder that affects the esophagus. Representative examples of non-neoplastic disorders include esophagitis and esophageal ulcer. Representative examples of neoplastic disorders include carcinomas, lymphomas, and melanomas.

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Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 K23*
  • Cause of death: ICD-10 K23*

2 out of 7 registries used, show all original rules.

643

4. Check minimum number of events

None

643

5. Include endpoints

None

643

6. Filter based on genotype QC (FinnGen only)

620

Control definitions (FinnGen only)

Control exclude K11_OESSTODUO

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 4359 2111 2210
Only index persons 3741 1874 1867
Unadjusted period prevalence (%)
Whole population 0.06 0.06 0.06
Only index persons 0.07 0.07 0.07
Median age at first event (years)
Whole population 68.90 69.62 68.24
Only index persons 68.35 68.82 67.87

-FinnGen-

Key figures

All Female Male
Number of individuals 620 304 316
Unadjusted period prevalence (%) 0.14 0.12 0.16
Median age at first event (years) 66.44 64.25 68.54

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

Association

Association between endpoint K11_DISOESINOTH and mortality.

Females

Parameter HR [95% CI] p-value
K11_DISOESINOTH 2.565 [2.19, 3.01] < 0.001
Birth year 0.999 [0.99, 1.01] 0.903

During the follow-up period (1.1.1998 — 31.12.2019), 765 out of 1795 females with K11_DISOESINOTH died.

Males

Parameter HR [95% CI] p-value
K11_DISOESINOTH 3.311 [2.69, 4.07] < 0.001
Birth year 0.985 [0.97, 0.99] 0.002

During the follow-up period (1.1.1998 — 31.12.2019), 950 out of 1818 males with K11_DISOESINOTH died.

Mortality risk

Mortality risk for people of age

years, who have K11_DISOESINOTH.

N-year risk Females Males
1 0.301% 0.578%
5 1.533% 3.549%
10 4.232% 8.764%
15 8.451% 15.944%
20 14.532% 26.073%

Relationships between endpoints

Index endpoint: K11_DISOESINOTH – Disorders of oesophagus in diseases classified elsewhere

GWS hits: 1

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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