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Oesophagitis

DOID EFO Endpoint Browser PheWeb

K11_OESITIS

Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — K20
  • Hospital discharge: ICD-9 — 5301
  • Hospital discharge: ICD-8 — 5301
  • Hospital discharge: excluded ICD-9 — 5301A
  • Cause of death: ICD-10 — K20
  • Cause of death: ICD-9 — 5301
  • Cause of death: ICD-8 — 5301
  • Cause of death: excluded ICD-9 — 5301A

2 out of 7 registries used, show all original rules.

1899

4. Check minimum number of events

None

1899

5. Include endpoints

None

1899

6. Filter based on genotype QC (FinnGen only)

1825

Control definitions (FinnGen only)

Control exclude K11_OESSTODUO

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 K00-K14
Name in latin Oesophagitis

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 18100 7510 10360
Only index persons 13636 5932 7704
Unadjusted period prevalence (%)
Whole population 0.26 0.22 0.29
Only index persons 0.26 0.22 0.29
Median age at first event (years)
Whole population 59.68 62.33 57.59
Only index persons 56.85 58.87 55.29

-FinnGen-

Key figures

All Female Male
Number of individuals 1825 806 1019
Unadjusted period prevalence (%) 0.43 0.32 0.51
Median age at first event (years) 56.53 54.18 58.38

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Association

Association between endpoint K11_OESITIS and mortality.

Females

Parameter HR [95% CI] p-value
K11_OESITIS 1.743 [1.58, 1.93] < 0.001
Birth year 0.997 [0.99, 1.01] 0.445

During the follow-up period (1.1.1998 — 31.12.2019), 1669 out of 4958 females with K11_OESITIS died.

Males

Parameter HR [95% CI] p-value
K11_OESITIS 2.353 [2.11, 2.63] < 0.001
Birth year 0.983 [0.97, 0.99] < 0.001

During the follow-up period (1.1.1998 — 31.12.2019), 2620 out of 6523 males with K11_OESITIS died.

Mortality risk

Mortality risk for people of age

years, who have K11_OESITIS.

N-year risk Females Males
1 0.181% 0.434%
5 1.134% 2.288%
10 2.826% 5.936%
15 5.39% 11.12%
20 8.978% 18.237%

Relationships between endpoints

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Index endpoint: K11_OESITIS – Oesophagitis

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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