suppurative otitis media: Inflammation of the middle ear with purulent discharge.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
20918 |
4. Check minimum number of eventsNone |
20918 |
5. Include endpoints |
32729 |
6. Filter based on genotype QC (FinnGen only) |
31326 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
Level in the ICD hierarchy
2
First used in FinnGen datafreeze
DF2
Diseases of middle ear and mastoid
based on the number of shared cases.
Similar with more cases:
Similar with less cases:
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 653223 | 287415 | 364512 |
| Only index persons | 498465 | 221011 | 277454 |
| Unadjusted period prevalence (%) | |||
| Whole population | 9.31 | 8.23 | 10.18 |
| Only index persons | 9.50 | 8.12 | 10.59 |
| Median age at first event (years) | |||
| Whole population | 2.63 | 2.93 | 2.26 |
| Only index persons | 3.07 | 3.66 | 2.60 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 31326 | 18092 | 13234 |
| Unadjusted period prevalence (%) | 6.91 | 7.11 | 6.65 |
| Median age at first event (years) | 8.69 | 7.10 | 10.88 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint H8_MIDDLEMASTOID and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H8_MIDDLEMASTOID | 1.212 [1.07, 1.37] | 0.002 |
| Birth year | 0.992 [0.98, 1.0] | 0.06 |
During the follow-up period (1.1.1998 — 31.12.2019), 6474 out of 192975 females with H8_MIDDLEMASTOID died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H8_MIDDLEMASTOID | 1.238 [1.09, 1.41] | 0.001 |
| Birth year | 0.986 [0.98, 1.0] | 0.003 |
During the follow-up period (1.1.1998 — 31.12.2019), 7198 out of 228892 males with H8_MIDDLEMASTOID died.
Mortality risk
Mortality risk for people of age
years, who have H8_MIDDLEMASTOID.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.074% | 0.303% |
| 5 | 0.527% | 1.542% |
| 10 | 1.485% | 3.535% |
| 15 | 2.983% | 6.528% |
| 20 | 5.028% | 11.279% |
Relationships between endpoints
↥Index endpoint: H8_MIDDLEMASTOID – Diseases of middle ear and mastoid
GWS hits: 14
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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