Chronic myringitis

H8_MYRINGCHRON

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 H73.1
  • Hospital discharge: ICD-9 3841
  • Cause of death: ICD-10 H73.1
  • Cause of death: ICD-9 3841

2 out of 7 registries used, show all original rules.

145

4. Check minimum number of events

None

145

5. Include endpoints

None

145

6. Filter based on genotype QC (FinnGen only)

139

Control definitions (FinnGen only)

Control exclude H8_MIDDLEMASTOID

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 H73
Name in latin Myringitis chronica

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 1468 726 734
Only index persons 1375 692 683
Unadjusted period prevalence (%)
Whole population 0.02 0.02 0.02
Only index persons 0.03 0.03 0.03
Median age at first event (years)
Whole population 43.87 44.67 43.07
Only index persons 44.96 45.66 44.24

-FinnGen-

Key figures

All Female Male
Number of individuals 139 77 62
Unadjusted period prevalence (%) 0.03 0.03 0.03
Median age at first event (years) 56.23 55.17 57.55

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

Mortality – FinRegistry

Association

Association between endpoint H8_MYRINGCHRON and mortality.

Females

Parameter HR [95% CI] p-value
H8_MYRINGCHRON 0.971 [0.69, 1.37] 0.867
Birth year 0.995 [0.99, 1.0] 0.274

During the follow-up period (1.1.1998 — 31.12.2019), 51 out of 610 females with H8_MYRINGCHRON died.

Males

Parameter HR [95% CI] p-value
H8_MYRINGCHRON 0.866 [0.64, 1.18] 0.359
Birth year 0.987 [0.98, 1.0] 0.006

During the follow-up period (1.1.1998 — 31.12.2019), 53 out of 607 males with H8_MYRINGCHRON died.

Mortality risk

Mortality risk for people of age

years, who have H8_MYRINGCHRON.

N-year risk Females Males
1 0.117% 0.183%
5 0.575% 0.998%
10 1.505% 2.504%
15 2.861% 4.861%
20 4.939% 8.169%

Relationships between endpoints

Index endpoint: H8_MYRINGCHRON – Chronic myringitis

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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