No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
886 |
4. Check minimum number of eventsNone |
886 |
5. Include endpointsNone |
886 |
6. Filter based on genotype QC (FinnGen only) |
857 |
Control definitions (FinnGen only)
Control exclude
H8_MIDDLEMASTOID
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
H70
Name in latin
Mastoiditis chronica
Similar endpoints
↥List of similar endpoints to
Chronic mastoiditis
based on the number of shared cases.
Similar with more cases:
- Diseases of middle ear and mastoid
- Diseases of the ear and mastoid process
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 8589 | 3987 | 4494 |
| Only index persons | 7007 | 3397 | 3610 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.12 | 0.11 | 0.13 |
| Only index persons | 0.13 | 0.12 | 0.14 |
| Median age at first event (years) | |||
| Whole population | 40.57 | 43.01 | 38.15 |
| Only index persons | 37.44 | 40.07 | 34.97 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 857 | 377 | 480 |
| Unadjusted period prevalence (%) | 0.20 | 0.15 | 0.24 |
| Median age at first event (years) | 41.54 | 40.38 | 42.45 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
Mortality – FinRegistry
↥Association
Association between endpoint H8_MASTCHRON and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H8_MASTCHRON | 1.062 [0.92, 1.23] | 0.423 |
| Birth year | 0.993 [0.98, 1.0] | 0.116 |
During the follow-up period (1.1.1998 — 31.12.2019), 301 out of 1336 females with H8_MASTCHRON died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H8_MASTCHRON | 1.065 [0.91, 1.24] | 0.417 |
| Birth year | 0.987 [0.98, 1.0] | 0.007 |
During the follow-up period (1.1.1998 — 31.12.2019), 353 out of 1435 males with H8_MASTCHRON died.
Mortality risk
Mortality risk for people of age
years, who have H8_MASTCHRON.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.084% | 0.166% |
| 5 | 0.55% | 1.315% |
| 10 | 1.418% | 3.106% |
| 15 | 2.849% | 5.996% |
| 20 | 5.255% | 10.158% |
Relationships between endpoints
↥Index endpoint: H8_MASTCHRON – Chronic mastoiditis
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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