Chronic mastoiditis

H8_MASTCHRON

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 H70.1
  • Hospital discharge: ICD-9 3831
  • Hospital discharge: ICD-8 3821|3831
  • Cause of death: ICD-10 H70.1
  • Cause of death: ICD-9 3831
  • Cause of death: ICD-8 3821|3831

2 out of 7 registries used, show all original rules.

886

4. Check minimum number of events

None

886

5. Include endpoints

None

886

6. Filter based on genotype QC (FinnGen only)

857

Control definitions (FinnGen only)

Control exclude H8_MIDDLEMASTOID

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 H70
Name in latin Mastoiditis chronica

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 8589 3987 4494
Only index persons 7007 3397 3610
Unadjusted period prevalence (%)
Whole population 0.12 0.11 0.13
Only index persons 0.13 0.12 0.14
Median age at first event (years)
Whole population 40.57 43.01 38.15
Only index persons 37.44 40.07 34.97

-FinnGen-

Key figures

All Female Male
Number of individuals 857 377 480
Unadjusted period prevalence (%) 0.20 0.15 0.24
Median age at first event (years) 41.54 40.38 42.45

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

Mortality – FinRegistry

Association

Association between endpoint H8_MASTCHRON and mortality.

Females

Parameter HR [95% CI] p-value
H8_MASTCHRON 1.062 [0.92, 1.23] 0.423
Birth year 0.993 [0.98, 1.0] 0.116

During the follow-up period (1.1.1998 — 31.12.2019), 301 out of 1336 females with H8_MASTCHRON died.

Males

Parameter HR [95% CI] p-value
H8_MASTCHRON 1.065 [0.91, 1.24] 0.417
Birth year 0.987 [0.98, 1.0] 0.007

During the follow-up period (1.1.1998 — 31.12.2019), 353 out of 1435 males with H8_MASTCHRON died.

Mortality risk

Mortality risk for people of age

years, who have H8_MASTCHRON.

N-year risk Females Males
1 0.084% 0.166%
5 0.55% 1.315%
10 1.418% 3.106%
15 2.849% 5.996%
20 5.255% 10.158%

Relationships between endpoints

Index endpoint: H8_MASTCHRON – Chronic mastoiditis

GWS hits: 1

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
loading spinner Loading data