No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
3676 |
4. Check minimum number of eventsNone |
3676 |
5. Include endpointsNone |
3676 |
6. Filter based on genotype QC (FinnGen only) |
3488 |
Control definitions (FinnGen only)
Control exclude
H8_MIDDLEMASTOID
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
H65-H75
Name in latin
Perforatio membranae tympanicae
Similar endpoints
↥List of similar endpoints to
Perforation of tympanic membrane
based on the number of shared cases.
Similar with more cases:
- Diseases of middle ear and mastoid
- Diseases of the ear and mastoid process
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 39492 | 18838 | 20408 |
| Only index persons | 35816 | 17317 | 18499 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.55 | 0.54 | 0.57 |
| Only index persons | 0.67 | 0.64 | 0.71 |
| Median age at first event (years) | |||
| Whole population | 38.96 | 43.48 | 34.79 |
| Only index persons | 39.96 | 44.51 | 35.70 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 3488 | 1917 | 1571 |
| Unadjusted period prevalence (%) | 0.77 | 0.75 | 0.79 |
| Median age at first event (years) | 51.35 | 48.69 | 54.59 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint H8_PERFORATION and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H8_PERFORATION | 1.099 [0.99, 1.22] | 0.071 |
| Birth year | 0.996 [0.99, 1.0] | 0.37 |
During the follow-up period (1.1.1998 — 31.12.2019), 1840 out of 14921 females with H8_PERFORATION died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H8_PERFORATION | 1.182 [1.07, 1.31] | 0.001 |
| Birth year | 0.988 [0.98, 1.0] | 0.01 |
During the follow-up period (1.1.1998 — 31.12.2019), 2140 out of 16352 males with H8_PERFORATION died.
Mortality risk
Mortality risk for people of age
years, who have H8_PERFORATION.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.103% | 0.211% |
| 5 | 0.734% | 1.322% |
| 10 | 1.628% | 3.392% |
| 15 | 2.984% | 6.549% |
| 20 | 5.382% | 11.176% |
Relationships between endpoints
↥Index endpoint: H8_PERFORATION – Perforation of tympanic membrane
GWS hits: 3
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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