Perforation of tympanic membrane

H8_PERFORATION

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 H72
  • Hospital discharge: ICD-9 3842
  • Cause of death: ICD-10 H72
  • Cause of death: ICD-9 3842

2 out of 7 registries used, show all original rules.

3676

4. Check minimum number of events

None

3676

5. Include endpoints

None

3676

6. Filter based on genotype QC (FinnGen only)

3488

Control definitions (FinnGen only)

Control exclude H8_MIDDLEMASTOID

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 H65-H75
Name in latin Perforatio membranae tympanicae

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 39492 18838 20408
Only index persons 35816 17317 18499
Unadjusted period prevalence (%)
Whole population 0.55 0.54 0.57
Only index persons 0.67 0.64 0.71
Median age at first event (years)
Whole population 38.96 43.48 34.79
Only index persons 39.96 44.51 35.70

-FinnGen-

Key figures

All Female Male
Number of individuals 3488 1917 1571
Unadjusted period prevalence (%) 0.77 0.75 0.79
Median age at first event (years) 51.35 48.69 54.59

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

Association

Association between endpoint H8_PERFORATION and mortality.

Females

Parameter HR [95% CI] p-value
H8_PERFORATION 1.099 [0.99, 1.22] 0.071
Birth year 0.996 [0.99, 1.0] 0.37

During the follow-up period (1.1.1998 — 31.12.2019), 1840 out of 14921 females with H8_PERFORATION died.

Males

Parameter HR [95% CI] p-value
H8_PERFORATION 1.182 [1.07, 1.31] 0.001
Birth year 0.988 [0.98, 1.0] 0.01

During the follow-up period (1.1.1998 — 31.12.2019), 2140 out of 16352 males with H8_PERFORATION died.

Mortality risk

Mortality risk for people of age

years, who have H8_PERFORATION.

N-year risk Females Males
1 0.103% 0.211%
5 0.734% 1.322%
10 1.628% 3.392%
15 2.984% 6.549%
20 5.382% 11.176%

Relationships between endpoints

Index endpoint: H8_PERFORATION – Perforation of tympanic membrane

GWS hits: 3

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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