cholesteatoma of middle ear: A non-neoplastic lesion characterized by the proliferation of keratinizing squamous epithelium in the middle ear that results in the accumulation of keratin and cells. It is usually caused by repeated infections. If left untreated, it may increase in size and destroy the adjacent delicate bones of the middle ear.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
1791 |
4. Check minimum number of eventsNone |
1791 |
5. Include endpointsNone |
1791 |
6. Filter based on genotype QC (FinnGen only) |
1710 |
Control definitions (FinnGen only)
Extra metadata
Similar endpoints
↥List of similar endpoints to Cholesteatoma of middle ear based on the number of shared cases.
Similar with more cases:
- Diseases of middle ear and mastoid
- Diseases of the ear and mastoid process
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥Summary Statistics
↥-FinRegistry-
Key figures
All | Female | Male | |
---|---|---|---|
Number of individuals | |||
Whole population | 17391 | 7390 | 9876 |
Only index persons | 15196 | 6641 | 8555 |
Unadjusted period prevalence (%) | |||
Whole population | 0.25 | 0.21 | 0.28 |
Only index persons | 0.29 | 0.24 | 0.33 |
Median age at first event (years) | |||
Whole population | 46.07 | 49.35 | 43.53 |
Only index persons | 44.52 | 48.24 | 41.62 |
-FinnGen-
Key figures
All | Female | Male | |
---|---|---|---|
Number of individuals | 1710 | 751 | 959 |
Unadjusted period prevalence (%) | 0.40 | 0.29 | 0.48 |
Median age at first event (years) | 48.47 | 46.66 | 49.89 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint H8_CHOLEASTOMA and mortality.
Females
Parameter | HR [95% CI] | p-value |
---|---|---|
H8_CHOLEASTOMA | 1.047 [0.94, 1.16] | 0.395 |
Birth year | 0.997 [0.99, 1.01] | 0.45 |
During the follow-up period (1.1.1998 — 31.12.2019), 785 out of 4102 females with H8_CHOLEASTOMA died.
Males
Parameter | HR [95% CI] | p-value |
---|---|---|
H8_CHOLEASTOMA | 1.029 [0.93, 1.14] | 0.572 |
Birth year | 0.99 [0.98, 1.0] | 0.038 |
During the follow-up period (1.1.1998 — 31.12.2019), 1025 out of 5237 males with H8_CHOLEASTOMA died.
Mortality risk
Mortality risk for people of age
years, who have H8_CHOLEASTOMA.N-year risk | Females | Males |
---|---|---|
1 | 0.123% | 0.193% |
5 | 0.634% | 1.217% |
10 | 1.682% | 3.257% |
15 | 3.035% | 6.167% |
20 | 5.517% | 10.486% |
Relationships between endpoints
↥Index endpoint: H8_CHOLEASTOMA – Cholesteatoma of middle ear
GWS hits: 2