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Acute mastoiditis

DOID EFO Endpoint Browser PheWeb

H8_MASTACU

Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — H70.0
  • Hospital discharge: ICD-9 — 3830
  • Hospital discharge: ICD-8 — 3820|3830
  • Cause of death: ICD-10 — H70.0
  • Cause of death: ICD-9 — 3830
  • Cause of death: ICD-8 — 3820|3830

2 out of 7 registries used, show all original rules.

307

4. Check minimum number of events

None

307

5. Include endpoints

None

307

6. Filter based on genotype QC (FinnGen only)

297

Control definitions (FinnGen only)

Control exclude H8_MIDDLEMASTOID

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF6
Parent code in ICD-10 H70
Name in latin Mastoiditis acuta

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 3448 1399 2033
Only index persons 3116 1283 1833
Unadjusted period prevalence (%)
Whole population 0.05 0.04 0.06
Only index persons 0.06 0.05 0.07
Median age at first event (years)
Whole population 20.70 22.79 19.10
Only index persons 20.06 21.89 18.78

-FinnGen-

Key figures

All Female Male
Number of individuals 297 154 143
Unadjusted period prevalence (%) 0.07 0.06 0.07
Median age at first event (years) 25.77 30.75 20.41

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

Mortality – FinRegistry

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Association

Association between endpoint H8_MASTACU and mortality.

Females

Parameter HR [95% CI] p-value
H8_MASTACU 1.511 [1.14, 2.01] 0.004
Birth year 0.996 [0.99, 1.0] 0.347

During the follow-up period (1.1.1998 — 31.12.2019), 63 out of 695 females with H8_MASTACU died.

Males

Parameter HR [95% CI] p-value
H8_MASTACU 1.681 [1.23, 2.29] 0.001
Birth year 0.987 [0.98, 1.0] 0.006

During the follow-up period (1.1.1998 — 31.12.2019), 95 out of 630 males with H8_MASTACU died.

Mortality risk

Mortality risk for people of age

years, who have H8_MASTACU.

N-year risk Females Males
1 0.155% 0.291%
5 0.85% 1.9%
10 2.049% 4.692%
15 4.027% 8.837%
20 7.316% 14.976%

Relationships between endpoints

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Index endpoint: H8_MASTACU – Acute mastoiditis

GWS hits: 1

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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