Other disorders of Eustachian tube

H8_EUSTNAS

auditory system disease: Pathological processes of the ear, the hearing, and the equilibrium system of the body.

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Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 H69
  • Hospital discharge: ICD-9 381[7-9]
  • Cause of death: ICD-10 H69
  • Cause of death: ICD-9 381[7-9]

2 out of 7 registries used, show all original rules.

938

4. Check minimum number of events

None

938

5. Include endpoints

None

938

6. Filter based on genotype QC (FinnGen only)

897

Control definitions (FinnGen only)

Control exclude H8_MIDDLEMASTOID

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 H65-H75
Name in latin Aliae morbositates tubae auditivae

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 6062 3566 2467
Only index persons 5812 3458 2354
Unadjusted period prevalence (%)
Whole population 0.09 0.10 0.07
Only index persons 0.11 0.13 0.09
Median age at first event (years)
Whole population 48.24 47.07 49.93
Only index persons 48.07 46.99 49.66

-FinnGen-

Key figures

All Female Male
Number of individuals 897 580 317
Unadjusted period prevalence (%) 0.20 0.23 0.16
Median age at first event (years) 54.92 51.45 61.29

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

Association

Association between endpoint H8_EUSTNAS and mortality.

Females

Parameter HR [95% CI] p-value
H8_EUSTNAS 1.042 [0.88, 1.23] 0.633
Birth year 0.993 [0.98, 1.0] 0.101

During the follow-up period (1.1.1998 — 31.12.2019), 209 out of 2905 females with H8_EUSTNAS died.

Males

Parameter HR [95% CI] p-value
H8_EUSTNAS 1.333 [1.11, 1.6] 0.002
Birth year 0.985 [0.98, 0.99] 0.003

During the follow-up period (1.1.1998 — 31.12.2019), 270 out of 1926 males with H8_EUSTNAS died.

Mortality risk

Mortality risk for people of age

years, who have H8_EUSTNAS.

N-year risk Females Males
1 0.114% 0.267%
5 0.58% 1.539%
10 1.468% 3.684%
15 2.676% 6.729%
20 4.803% 11.652%

Relationships between endpoints

Index endpoint: H8_EUSTNAS – Other disorders of Eustachian tube

GWS hits: 2

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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