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Acute suppurative otitis media

DOID EFO Endpoint Browser PheWeb

H8_SUP_ACUTE

Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — H66.0
  • Hospital discharge: ICD-9 — 3820
  • Hospital discharge: ICD-8 — 3810
  • Cause of death: ICD-10 — H66.0
  • Cause of death: ICD-9 — 3820
  • Cause of death: ICD-8 — 3810

2 out of 7 registries used, show all original rules.

13115

4. Check minimum number of events

None

13115

5. Include endpoints

None

13115

6. Filter based on genotype QC (FinnGen only)

12552

Control definitions (FinnGen only)

Control exclude H8_MIDDLEMASTOID

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2
Parent code in ICD-10 H66
Name in latin Otitis media suppurativa acuta

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 310305 134839 175144
Only index persons 216706 94235 122471
Unadjusted period prevalence (%)
Whole population 4.44 3.86 4.89
Only index persons 4.15 3.46 4.68
Median age at first event (years)
Whole population 2.08 2.27 1.89
Only index persons 2.27 2.63 2.00

-FinnGen-

Key figures

All Female Male
Number of individuals 12552 7310 5242
Unadjusted period prevalence (%) 2.77 2.87 2.63
Median age at first event (years) 3.40 3.58 3.17

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Association

Association between endpoint H8_SUP_ACUTE and mortality.

Females

Parameter HR [95% CI] p-value
H8_SUP_ACUTE 1.662 [1.28, 2.16] < 0.001
Birth year 0.988 [0.98, 1.0] 0.007

During the follow-up period (1.1.1998 — 31.12.2019), 1469 out of 92759 females with H8_SUP_ACUTE died.

Males

Parameter HR [95% CI] p-value
H8_SUP_ACUTE 1.533 [1.24, 1.89] < 0.001
Birth year 0.986 [0.98, 1.0] 0.004

During the follow-up period (1.1.1998 — 31.12.2019), 1685 out of 110560 males with H8_SUP_ACUTE died.

Mortality risk

Mortality risk for people of age

years, who have H8_SUP_ACUTE.

N-year risk Females Males
1 0.091% 0.292%
5 0.763% 1.868%
10 1.952% 4.341%
15 3.509% 8.349%
20 6.052% 13.825%

Relationships between endpoints

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Index endpoint: H8_SUP_ACUTE – Acute suppurative otitis media

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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