Otitis media: Inflammation of the anatomical structures of the middle ear, which is most often caused by an infectious process. Symptoms include erythema and edema of the tympanic membrane, pain, and possibly fever.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersNone 0 out of 7 registries used, show all original rules. |
0 |
4. Check minimum number of eventsNone |
0 |
5. Include endpoints |
19044 |
6. Filter based on genotype QC (FinnGen only) |
18213 |
Control definitions (FinnGen only)
Control exclude
H8_MIDDLEMASTOID
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Similar endpoints
↥List of similar endpoints to
Suppurative and unspecified otitis media
based on the number of shared cases.
Similar with more cases:
- Diseases of middle ear and mastoid
- Diseases of the ear and mastoid process
- Any event in hilmo or specialist outpatient
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 443858 | 195631 | 247526 |
| Only index persons | 319318 | 141551 | 177767 |
| Unadjusted period prevalence (%) | |||
| Whole population | 6.33 | 5.60 | 6.92 |
| Only index persons | 6.08 | 5.20 | 6.79 |
| Median age at first event (years) | |||
| Whole population | 2.29 | 2.51 | 2.02 |
| Only index persons | 2.60 | 3.08 | 2.21 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 18213 | 10619 | 7594 |
| Unadjusted period prevalence (%) | 4.02 | 4.17 | 3.81 |
| Median age at first event (years) | 6.00 | 5.77 | 6.32 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint H8_MED_SUPP and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H8_MED_SUPP | 1.211 [1.04, 1.4] | 0.011 |
| Birth year | 0.994 [0.99, 1.0] | 0.165 |
During the follow-up period (1.1.1998 — 31.12.2019), 2993 out of 138272 females with H8_MED_SUPP died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H8_MED_SUPP | 1.251 [1.04, 1.5] | 0.015 |
| Birth year | 0.985 [0.98, 0.99] | 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 3357 out of 163651 males with H8_MED_SUPP died.
Mortality risk
Mortality risk for people of age
years, who have H8_MED_SUPP.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.15% | 0.214% |
| 5 | 0.724% | 1.366% |
| 10 | 1.789% | 3.396% |
| 15 | 3.346% | 6.425% |
| 20 | 5.97% | 10.738% |
Relationships between endpoints
↥Index endpoint: H8_MED_SUPP – Suppurative and unspecified otitis media
GWS hits: 2
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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