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Chronic suppurative otitis media

DOID EFO Endpoint Browser PheWeb

H8_CHRON_SUPOTITIS

Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — H66.1, H66.2, H66.3
  • Hospital discharge: ICD-9 — 3821
  • Hospital discharge: ICD-8 — 3811
  • Cause of death: ICD-10 — H66.1, H66.2, H66.3
  • Cause of death: ICD-9 — 3821

2 out of 7 registries used, show all original rules.

2575

4. Check minimum number of events

None

2575

5. Include endpoints

None

2575

6. Filter based on genotype QC (FinnGen only)

2469

Control definitions (FinnGen only)

Control exclude H8_MIDDLEMASTOID

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 36319 15843 20247
Only index persons 29488 13262 16226
Unadjusted period prevalence (%)
Whole population 0.51 0.45 0.57
Only index persons 0.56 0.49 0.62
Median age at first event (years)
Whole population 11.18 15.82 7.08
Only index persons 10.85 15.70 6.89

-FinnGen-

Key figures

All Female Male
Number of individuals 2469 1233 1236
Unadjusted period prevalence (%) 0.55 0.48 0.62
Median age at first event (years) 29.25 25.48 33.01

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Association

Association between endpoint H8_CHRON_SUPOTITIS and mortality.

Females

Parameter HR [95% CI] p-value
H8_CHRON_SUPOTITIS 1.218 [1.07, 1.39] 0.003
Birth year 0.994 [0.99, 1.0] 0.171

During the follow-up period (1.1.1998 — 31.12.2019), 566 out of 6742 females with H8_CHRON_SUPOTITIS died.

Males

Parameter HR [95% CI] p-value
H8_CHRON_SUPOTITIS 1.217 [1.06, 1.4] 0.006
Birth year 0.985 [0.98, 0.99] 0.003

During the follow-up period (1.1.1998 — 31.12.2019), 673 out of 8885 males with H8_CHRON_SUPOTITIS died.

Mortality risk

Mortality risk for people of age

years, who have H8_CHRON_SUPOTITIS.

N-year risk Females Males
1 0.116% 0.167%
5 0.661% 1.295%
10 1.752% 3.212%
15 3.385% 6.503%
20 6.301% 10.844%

Relationships between endpoints

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Index endpoint: H8_CHRON_SUPOTITIS – Chronic suppurative otitis media

GWS hits: 2

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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