Otitis media, unspecified

H8_OTIMEDNAS

Otitis media: Inflammation of the anatomical structures of the middle ear, which is most often caused by an infectious process. Symptoms include erythema and edema of the tympanic membrane, pain, and possibly fever.

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Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 H66.9
  • Hospital discharge: ICD-8 3819
  • Cause of death: ICD-10 H66.9
  • Cause of death: ICD-8 3819

2 out of 7 registries used, show all original rules.

4803

4. Check minimum number of events

None

4803

5. Include endpoints

None

4803

6. Filter based on genotype QC (FinnGen only)

4573

Control definitions (FinnGen only)

Control exclude H8_MIDDLEMASTOID

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2
Parent code in ICD-10 H66
Name in latin Otitis media non specificata

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 149321 66988 82178
Only index persons 106058 48151 57907
Unadjusted period prevalence (%)
Whole population 2.12 1.92 2.30
Only index persons 2.01 1.77 2.21
Median age at first event (years)
Whole population 2.63 2.92 2.32
Only index persons 3.24 3.79 2.78

-FinnGen-

Key figures

All Female Male
Number of individuals 4573 2851 1722
Unadjusted period prevalence (%) 1.02 1.12 0.86
Median age at first event (years) 16.30 16.12 16.61

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

Association

Association between endpoint H8_OTIMEDNAS and mortality.

Females

Parameter HR [95% CI] p-value
H8_OTIMEDNAS 1.432 [1.19, 1.72] < 0.001
Birth year 0.995 [0.99, 1.0] 0.226

During the follow-up period (1.1.1998 — 31.12.2019), 1155 out of 59246 females with H8_OTIMEDNAS died.

Males

Parameter HR [95% CI] p-value
H8_OTIMEDNAS 1.551 [1.2, 2.01] < 0.001
Birth year 0.986 [0.98, 1.0] 0.005

During the follow-up period (1.1.1998 — 31.12.2019), 1256 out of 71952 males with H8_OTIMEDNAS died.

Mortality risk

Mortality risk for people of age

years, who have H8_OTIMEDNAS.

N-year risk Females Males
1 0.138% 0.314%
5 0.738% 1.785%
10 2.034% 4.318%
15 3.894% 8.33%
20 7.097% 14.033%

Relationships between endpoints

Index endpoint: H8_OTIMEDNAS – Otitis media, unspecified

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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