No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
566 |
4. Check minimum number of eventsNone |
566 |
5. Include endpointsNone |
566 |
6. Filter based on genotype QC (FinnGen only) |
540 |
Control definitions (FinnGen only)
Control exclude
H8_MIDDLEMASTOID
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
H74
Name in latin
Morbus adhaesivus auris mediae
Similar endpoints
↥List of similar endpoints to
Adhesive middle ear disease
based on the number of shared cases.
Similar with more cases:
- Diseases of middle ear and mastoid
- Diseases of the ear and mastoid process
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 7161 | 3318 | 3824 |
| Only index persons | 6710 | 3122 | 3588 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.10 | 0.10 | 0.11 |
| Only index persons | 0.13 | 0.11 | 0.14 |
| Median age at first event (years) | |||
| Whole population | 23.56 | 31.19 | 16.81 |
| Only index persons | 23.60 | 31.18 | 17.00 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 540 | 305 | 235 |
| Unadjusted period prevalence (%) | 0.12 | 0.12 | 0.12 |
| Median age at first event (years) | 42.24 | 40.51 | 44.49 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint H8_MIDDLEADDH and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H8_MIDDLEADDH | 1.106 [0.97, 1.26] | 0.133 |
| Birth year | 0.997 [0.99, 1.01] | 0.534 |
During the follow-up period (1.1.1998 — 31.12.2019), 364 out of 2840 females with H8_MIDDLEADDH died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H8_MIDDLEADDH | 0.981 [0.85, 1.13] | 0.785 |
| Birth year | 0.985 [0.98, 0.99] | 0.002 |
During the follow-up period (1.1.1998 — 31.12.2019), 343 out of 3211 males with H8_MIDDLEADDH died.
Mortality risk
Mortality risk for people of age
years, who have H8_MIDDLEADDH.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.124% | 0.176% |
| 5 | 0.686% | 1.216% |
| 10 | 1.732% | 2.881% |
| 15 | 3.336% | 5.368% |
| 20 | 5.743% | 8.851% |
Relationships between endpoints
↥Index endpoint: H8_MIDDLEADDH – Adhesive middle ear disease
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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