Discontinuity and dislocation of ear ossicles

H8_DISCON

Otitis media: Inflammation of the anatomical structures of the middle ear, which is most often caused by an infectious process. Symptoms include erythema and edema of the tympanic membrane, pain, and possibly fever.

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Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 H74.2
  • Cause of death: ICD-10 H74.2

2 out of 7 registries used, show all original rules.

167

4. Check minimum number of events

None

167

5. Include endpoints

None

167

6. Filter based on genotype QC (FinnGen only)

154

Control definitions (FinnGen only)

Control exclude H8_MIDDLEMASTOID

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 H74
Name in latin Discontinuitas ossiculorum auditoriorum

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 1329 614 704
Only index persons 1268 593 675
Unadjusted period prevalence (%)
Whole population 0.02 0.02 0.02
Only index persons 0.02 0.02 0.03
Median age at first event (years)
Whole population 44.71 48.15 41.81
Only index persons 45.31 48.21 42.77

-FinnGen-

Key figures

All Female Male
Number of individuals 154 85 69
Unadjusted period prevalence (%) 0.03 0.03 0.03
Median age at first event (years) 53.04 50.38 56.32

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

Mortality – FinRegistry

Association

Association between endpoint H8_DISCON and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have H8_DISCON.

N-year risk Females Males
1 No data No data
5 No data No data
10 No data No data
15 No data No data
20 No data No data

Relationships between endpoints

Index endpoint: H8_DISCON – Discontinuity and dislocation of ear ossicles

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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