Eustachian salpingitis and obstruction

H8_EUSTSALP

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 H68
  • Hospital discharge: ICD-9 3816
  • Hospital discharge: ICD-8 3840[0-2]
  • Cause of death: ICD-10 H68
  • Cause of death: ICD-9 3816
  • Cause of death: ICD-8 3840[0-2]

2 out of 7 registries used, show all original rules.

3120

4. Check minimum number of events

None

3120

5. Include endpoints

None

3120

6. Filter based on genotype QC (FinnGen only)

3029

Control definitions (FinnGen only)

Control exclude H8_MIDDLEMASTOID

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF4

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 31754 13543 18131
Only index persons 30023 12880 17143
Unadjusted period prevalence (%)
Whole population 0.45 0.39 0.51
Only index persons 0.58 0.47 0.65
Median age at first event (years)
Whole population 5.11 5.81 4.58
Only index persons 5.10 5.83 4.54

-FinnGen-

Key figures

All Female Male
Number of individuals 3029 1702 1327
Unadjusted period prevalence (%) 0.67 0.67 0.67
Median age at first event (years) 6.49 6.81 6.07

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

Association

Association between endpoint H8_EUSTSALP and mortality.

Females

Parameter HR [95% CI] p-value
H8_EUSTSALP 0.882 [0.71, 1.09] 0.255
Birth year 0.993 [0.98, 1.0] 0.125

During the follow-up period (1.1.1998 — 31.12.2019), 109 out of 3289 females with H8_EUSTSALP died.

Males

Parameter HR [95% CI] p-value
H8_EUSTSALP 0.873 [0.69, 1.1] 0.243
Birth year 0.99 [0.98, 1.0] 0.032

During the follow-up period (1.1.1998 — 31.12.2019), 112 out of 2993 males with H8_EUSTSALP died.

Mortality risk

Mortality risk for people of age

years, who have H8_EUSTSALP.

N-year risk Females Males
1 0.092% 0.177%
5 0.469% 1.006%
10 1.221% 2.684%
15 2.401% 5.315%
20 4.328% 9.138%

Relationships between endpoints

Index endpoint: H8_EUSTSALP – Eustachian salpingitis and obstruction

GWS hits: 1

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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