No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
3120 |
4. Check minimum number of eventsNone |
3120 |
5. Include endpointsNone |
3120 |
6. Filter based on genotype QC (FinnGen only) |
3029 |
Control definitions (FinnGen only)
Control exclude
H8_MIDDLEMASTOID
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF4
Similar endpoints
↥List of similar endpoints to
Eustachian salpingitis and obstruction
based on the number of shared cases.
Similar with more cases:
- Diseases of middle ear and mastoid
- Diseases of the ear and mastoid process
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 31754 | 13543 | 18131 |
| Only index persons | 30023 | 12880 | 17143 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.45 | 0.39 | 0.51 |
| Only index persons | 0.58 | 0.47 | 0.65 |
| Median age at first event (years) | |||
| Whole population | 5.11 | 5.81 | 4.58 |
| Only index persons | 5.10 | 5.83 | 4.54 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 3029 | 1702 | 1327 |
| Unadjusted period prevalence (%) | 0.67 | 0.67 | 0.67 |
| Median age at first event (years) | 6.49 | 6.81 | 6.07 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint H8_EUSTSALP and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H8_EUSTSALP | 0.882 [0.71, 1.09] | 0.255 |
| Birth year | 0.993 [0.98, 1.0] | 0.125 |
During the follow-up period (1.1.1998 — 31.12.2019), 109 out of 3289 females with H8_EUSTSALP died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H8_EUSTSALP | 0.873 [0.69, 1.1] | 0.243 |
| Birth year | 0.99 [0.98, 1.0] | 0.032 |
During the follow-up period (1.1.1998 — 31.12.2019), 112 out of 2993 males with H8_EUSTSALP died.
Mortality risk
Mortality risk for people of age
years, who have H8_EUSTSALP.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.092% | 0.177% |
| 5 | 0.469% | 1.006% |
| 10 | 1.221% | 2.684% |
| 15 | 2.401% | 5.315% |
| 20 | 4.328% | 9.138% |
Relationships between endpoints
↥Index endpoint: H8_EUSTSALP – Eustachian salpingitis and obstruction
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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