endocrine system disease: A disease involving the endocrine system.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
15186 |
4. Check minimum number of eventsNone |
15186 |
5. Include endpoints |
19717 |
6. Filter based on genotype QC (FinnGen only) |
18839 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
Level in the ICD hierarchy
2
First used in FinnGen datafreeze
DF2
Disorders of other endocrine glands
based on the number of shared cases.
Similar with more cases:
Similar with less cases:
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 187093 | 127000 | 58603 |
| Only index persons | 151332 | 103223 | 48109 |
| Unadjusted period prevalence (%) | |||
| Whole population | 2.99 | 3.64 | 1.64 |
| Only index persons | 3.17 | 3.79 | 1.84 |
| Median age at first event (years) | |||
| Whole population | 51.72 | 55.98 | 42.27 |
| Only index persons | 48.90 | 52.09 | 42.05 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 18839 | 12620 | 6219 |
| Unadjusted period prevalence (%) | 4.35 | 4.96 | 3.12 |
| Median age at first event (years) | 50.68 | 48.20 | 55.70 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint E4_ENDOGLAND and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_ENDOGLAND | 1.497 [1.39, 1.61] | < 0.001 |
| Birth year | 0.993 [0.99, 1.0] | 0.066 |
During the follow-up period (1.1.1998 — 31.12.2019), 27676 out of 95230 females with E4_ENDOGLAND died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_ENDOGLAND | 1.897 [1.73, 2.08] | < 0.001 |
| Birth year | 0.993 [0.98, 1.0] | 0.127 |
During the follow-up period (1.1.1998 — 31.12.2019), 9485 out of 44141 males with E4_ENDOGLAND died.
Mortality risk
Mortality risk for people of age
years, who have E4_ENDOGLAND.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.108% | 0.39% |
| 5 | 0.74% | 2.316% |
| 10 | 1.995% | 6.158% |
| 15 | 3.817% | 11.667% |
| 20 | 6.545% | 19.554% |
Relationships between endpoints
↥Index endpoint: E4_ENDOGLAND – Disorders of other endocrine glands
GWS hits: 4
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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