No definition available.
Hypothalamic dysfunction, including iatrogenic, not elsewhere classified
E4_HYPOTHALDYSF
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
63 |
4. Check minimum number of eventsNone |
63 |
5. Include endpointsNone |
63 |
6. Filter based on genotype QC (FinnGen only) |
60 |
Control definitions (FinnGen only)
Control exclude
E4_ENDOGLAND
Extra metadata
Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Similar endpoints
↥List of similar endpoints to
Hypothalamic dysfunction, including iatrogenic, not elsewhere classified
based on the number of shared cases.
Similar with more cases:
- Exclusions for E4_PCOS_BROAD
- Developmental endpoint to exclude non autoimmune-cases from E4_HYTHY_AI_STRICT
- Disorders of other endocrine glands
- Exclusions for E4_PCOS_CONSORTIUM
- Used for control exclusion in common control thyroid runs
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 500 | 262 | 235 |
| Only index persons | 443 | 232 | 211 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.01 | 0.01 | 0.01 |
| Only index persons | 0.01 | 0.01 | 0.01 |
| Median age at first event (years) | |||
| Whole population | 36.55 | 37.24 | 35.34 |
| Only index persons | 34.34 | 35.41 | 33.16 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 60 | 36 | 24 |
| Unadjusted period prevalence (%) | 0.01 | 0.01 | 0.01 |
| Median age at first event (years) | 38.90 | 38.41 | 39.64 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
No data
-FinnGen-
Cumulative Incidence Function
No data
Mortality – FinRegistry
↥Association
Association between endpoint E4_HYPOTHALDYSF and mortality.
Females
No dataMales
No dataMortality risk
Mortality risk for people of age
years, who have E4_HYPOTHALDYSF.| N-year risk | Females | Males |
|---|---|---|
| 1 | No data | No data |
| 5 | No data | No data |
| 10 | No data | No data |
| 15 | No data | No data |
| 20 | No data | No data |
Relationships between endpoints
↥Index endpoint: E4_HYPOTHALDYSF – Hypothalamic dysfunction, including iatrogenic, not elsewhere classified
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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