hypopituitarism: A condition of diminution or cessation of secretion of one or more hormones from the anterior pituitary gland. This may result from surgical or radiation ablation, non-secretory pituitary neoplasms, metastatic tumors, infarction, pituitary apoplexy, infiltrative or granulomatous processes, and other conditions.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
3 out of 7 registries used, show all original rules. |
2457 |
4. Check minimum number of eventsNone |
2457 |
5. Include endpointsNone |
2457 |
6. Filter based on genotype QC (FinnGen only) |
2355 |
Control definitions (FinnGen only)
Control exclude
E4_ENDOGLAND
Extra metadata
Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Similar endpoints
↥List of similar endpoints to
Hypopituitarism
based on the number of shared cases.
Similar with more cases:
- Disorders of other endocrine glands
- Endocrine, nutritional and metabolic diseases
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 15672 | 5905 | 9659 |
| Only index persons | 13551 | 5010 | 8541 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.23 | 0.17 | 0.27 |
| Only index persons | 0.27 | 0.18 | 0.33 |
| Median age at first event (years) | |||
| Whole population | 41.91 | 39.45 | 43.37 |
| Only index persons | 42.21 | 38.87 | 44.17 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 2355 | 863 | 1492 |
| Unadjusted period prevalence (%) | 0.60 | 0.34 | 0.75 |
| Median age at first event (years) | 46.68 | 42.99 | 48.81 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint E4_HYPOPIT and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_HYPOPIT | 2.411 [2.07, 2.8] | < 0.001 |
| Birth year | 0.995 [0.99, 1.0] | 0.239 |
During the follow-up period (1.1.1998 — 31.12.2019), 540 out of 4131 females with E4_HYPOPIT died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_HYPOPIT | 1.663 [1.44, 1.92] | < 0.001 |
| Birth year | 0.983 [0.97, 0.99] | < 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 775 out of 6770 males with E4_HYPOPIT died.
Mortality risk
Mortality risk for people of age
years, who have E4_HYPOPIT.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.197% | 0.354% |
| 5 | 1.331% | 1.862% |
| 10 | 3.358% | 4.465% |
| 15 | 6.434% | 8.397% |
| 20 | 11.583% | 14.004% |
Relationships between endpoints
↥Index endpoint: E4_HYPOPIT – Hypopituitarism
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
Loading data