endocrine system disease: A disease involving the endocrine system.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
1877 |
4. Check minimum number of eventsNone |
1877 |
5. Include endpoints |
1986 |
6. Filter based on genotype QC (FinnGen only) |
1883 |
Control definitions (FinnGen only)
Control exclude
E4_ENDOGLAND
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Similar endpoints
↥List of similar endpoints to
Other endocrine disorders
based on the number of shared cases.
Similar with more cases:
- Disorders of other endocrine glands
- Endocrine, nutritional and metabolic diseases
- Any event in hilmo or specialist outpatient
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 31129 | 16403 | 14689 |
| Only index persons | 22605 | 12208 | 10397 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.44 | 0.47 | 0.41 |
| Only index persons | 0.42 | 0.45 | 0.40 |
| Median age at first event (years) | |||
| Whole population | 7.81 | 8.09 | 7.35 |
| Only index persons | 10.77 | 11.10 | 10.40 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 1883 | 1133 | 750 |
| Unadjusted period prevalence (%) | 0.42 | 0.44 | 0.38 |
| Median age at first event (years) | 16.97 | 17.38 | 16.34 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint E4_ENDODIS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_ENDODIS | 2.214 [1.89, 2.6] | < 0.001 |
| Birth year | 0.992 [0.98, 1.0] | 0.06 |
During the follow-up period (1.1.1998 — 31.12.2019), 836 out of 14401 females with E4_ENDODIS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_ENDODIS | 2.624 [2.25, 3.06] | < 0.001 |
| Birth year | 0.988 [0.98, 1.0] | 0.011 |
During the follow-up period (1.1.1998 — 31.12.2019), 808 out of 12884 males with E4_ENDODIS died.
Mortality risk
Mortality risk for people of age
years, who have E4_ENDODIS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.208% | 0.389% |
| 5 | 1.229% | 2.819% |
| 10 | 2.919% | 6.793% |
| 15 | 5.687% | 13.4% |
| 20 | 9.654% | 22.642% |
Relationships between endpoints
↥Index endpoint: E4_ENDODIS – Other endocrine disorders
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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