endocrine system disease: A disease involving the endocrine system.
Disorders of endocrine glands in diseases classified elsewhere
DOID EFO Endpoint Browser PheWeb
E4_ENDINOTH
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
57 |
4. Check minimum number of eventsNone |
57 |
5. Include endpointsNone |
57 |
6. Filter based on genotype QC (FinnGen only) |
55 |
Control definitions (FinnGen only)
Control exclude
E4_ENDOGLAND
Extra metadata
Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
E20-E35
Name in latin
Morbositates glandularum endocrinarum in morbis alibi classificatis
Similar endpoints
↥List of similar endpoints to
Disorders of endocrine glands in diseases classified elsewhere
based on the number of shared cases.
Similar with more cases:
- Other endocrine disorders
- Disorders of other endocrine glands
- Endocrine, nutritional and metabolic diseases
- Any operation in hilmo
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 359 | 201 | 156 |
| Only index persons | 303 | 172 | 131 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.01 | 0.01 | 0.00 |
| Only index persons | 0.01 | 0.01 | 0.01 |
| Median age at first event (years) | |||
| Whole population | 48.72 | 48.00 | 49.57 |
| Only index persons | 47.76 | 46.75 | 49.08 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 55 | 29 | 26 |
| Unadjusted period prevalence (%) | 0.01 | 0.01 | 0.01 |
| Median age at first event (years) | 50.52 | 53.92 | 46.73 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
No data
-FinnGen-
Cumulative Incidence Function
No data
Mortality – FinRegistry
↥Association
Association between endpoint E4_ENDINOTH and mortality.
Females
No dataMales
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_ENDINOTH | 2.635 [1.58, 4.39] | < 0.001 |
| Birth year | 0.989 [0.98, 1.0] | 0.016 |
During the follow-up period (1.1.1998 — 31.12.2019), 51 out of 142 males with E4_ENDINOTH died.
Mortality risk
Mortality risk for people of age
years, who have E4_ENDINOTH.| N-year risk | Females | Males |
|---|---|---|
| 1 | No data | 0.513% |
| 5 | No data | 3.446% |
| 10 | No data | 8.439% |
| 15 | No data | 15.679% |
| 20 | No data | 25.275% |
Relationships between endpoints
↥Index endpoint: E4_ENDINOTH – Disorders of endocrine glands in diseases classified elsewhere
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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