No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
292 |
4. Check minimum number of eventsNone |
292 |
5. Include endpointsNone |
292 |
6. Filter based on genotype QC (FinnGen only) |
279 |
Control definitions (FinnGen only)
Control exclude
E4_ENDOGLAND
Extra metadata
Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
E34
Name in latin
Syndroma carcinoides
Similar endpoints
↥List of similar endpoints to
Carcinoid syndrome
based on the number of shared cases.
Similar with more cases:
- Other endocrine disorders
- Disorders of other endocrine glands
- Endocrine, nutritional and metabolic diseases
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1609 | 854 | 744 |
| Only index persons | 1230 | 666 | 564 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.02 | 0.02 | 0.02 |
| Only index persons | 0.02 | 0.02 | 0.02 |
| Median age at first event (years) | |||
| Whole population | 64.12 | 63.82 | 64.35 |
| Only index persons | 62.75 | 62.30 | 63.27 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 279 | 133 | 146 |
| Unadjusted period prevalence (%) | 0.06 | 0.05 | 0.07 |
| Median age at first event (years) | 61.85 | 60.02 | 63.52 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
Mortality – FinRegistry
↥Association
Association between endpoint E4_CARCISDR and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_CARCISDR | 4.015 [3.24, 4.98] | < 0.001 |
| Birth year | 0.993 [0.98, 1.0] | 0.136 |
During the follow-up period (1.1.1998 — 31.12.2019), 304 out of 704 females with E4_CARCISDR died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_CARCISDR | 3.911 [3.06, 4.99] | < 0.001 |
| Birth year | 0.989 [0.98, 1.0] | 0.034 |
During the follow-up period (1.1.1998 — 31.12.2019), 305 out of 623 males with E4_CARCISDR died.
Mortality risk
Mortality risk for people of age
years, who have E4_CARCISDR.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.313% | 0.692% |
| 5 | 2.093% | 4.777% |
| 10 | 5.068% | 11.321% |
| 15 | 9.75% | 20.778% |
| 20 | 16.571% | 33.927% |
Relationships between endpoints
↥Index endpoint: E4_CARCISDR – Carcinoid syndrome
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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