endocrine system disease: A disease involving the endocrine system.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
703 |
4. Check minimum number of eventsNone |
703 |
5. Include endpointsNone |
703 |
6. Filter based on genotype QC (FinnGen only) |
681 |
Control definitions (FinnGen only)
Control exclude
E4_ENDOGLAND
Extra metadata
Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Similar endpoints
↥List of similar endpoints to
Endocrine disorders, other/unspecified
based on the number of shared cases.
Similar with more cases:
- Other endocrine disorders
- Disorders of other endocrine glands
- Endocrine, nutritional and metabolic diseases
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 4629 | 2915 | 1690 |
| Only index persons | 4059 | 2629 | 1430 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.07 | 0.08 | 0.05 |
| Only index persons | 0.08 | 0.10 | 0.05 |
| Median age at first event (years) | |||
| Whole population | 45.31 | 43.58 | 47.96 |
| Only index persons | 42.47 | 41.28 | 44.67 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 681 | 463 | 218 |
| Unadjusted period prevalence (%) | 0.16 | 0.18 | 0.11 |
| Median age at first event (years) | 43.94 | 40.70 | 50.81 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint E4_ENDODISNAS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_ENDODISNAS | 1.723 [1.5, 1.98] | < 0.001 |
| Birth year | 0.997 [0.99, 1.01] | 0.433 |
During the follow-up period (1.1.1998 — 31.12.2019), 435 out of 2137 females with E4_ENDODISNAS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_ENDODISNAS | 2.082 [1.77, 2.45] | < 0.001 |
| Birth year | 0.992 [0.98, 1.0] | 0.076 |
During the follow-up period (1.1.1998 — 31.12.2019), 361 out of 1294 males with E4_ENDODISNAS died.
Mortality risk
Mortality risk for people of age
years, who have E4_ENDODISNAS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.181% | 0.487% |
| 5 | 0.917% | 2.933% |
| 10 | 2.625% | 6.936% |
| 15 | 5.304% | 12.736% |
| 20 | 8.779% | 21.356% |
Relationships between endpoints
↥Index endpoint: E4_ENDODISNAS – Endocrine disorders, other/unspecified
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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