ovarian dysfunction: The inability of the ovaries to function.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleonly females |
265735 |
2. Check conditionsNone |
265735 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
2328 |
4. Check minimum number of eventsNone |
2328 |
5. Include endpoints |
2835 |
6. Filter based on genotype QC (FinnGen only) |
2661 |
Control definitions (FinnGen only)
Control exclude
E4_ENDOGLAND
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
E20-E35
Name in latin
Dysfunctio ovarialis
Similar endpoints
↥List of similar endpoints to
Ovarian dysfunction
based on the number of shared cases.
Similar with more cases:
- Disorders of other endocrine glands
- Endocrine, nutritional and metabolic diseases
- Any event in hilmo or specialist outpatient
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 17415 | 17415 | - |
| Only index persons | 16983 | 16983 | - |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.50 | 0.50 | - |
| Only index persons | 0.62 | 0.62 | - |
| Median age at first event (years) | |||
| Whole population | - | 28.41 | - |
| Only index persons | - | 28.30 | - |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 2661 | 2661 | - |
| Unadjusted period prevalence (%) | 1.05 | 1.05 | - |
| Median age at first event (years) | 29.81 | 29.81 | - |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint E4_OVARDYS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_OVARDYS | 1.99 [1.65, 2.4] | < 0.001 |
| Birth year | 0.995 [0.99, 1.0] | 0.284 |
During the follow-up period (1.1.1998 — 31.12.2019), 243 out of 12980 females with E4_OVARDYS died.
Males
No dataMortality risk
Mortality risk for people of age
years, who have E4_OVARDYS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.18% | No data |
| 5 | 1.088% | No data |
| 10 | 2.691% | No data |
| 15 | 5.534% | No data |
| 20 | 10.04% | No data |
Relationships between endpoints
↥Index endpoint: E4_OVARDYS – Ovarian dysfunction
GWS hits: 6
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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