Ovarian dysfunction

E4_OVARDYS

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

only females

265735

2. Check conditions

None

265735

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 E28
  • Cause of death: ICD-10 E28

2 out of 7 registries used, show all original rules.

2328

4. Check minimum number of events

None

2328

5. Include endpoints

2835

6. Filter based on genotype QC (FinnGen only)

2661

Control definitions (FinnGen only)

Control exclude E4_ENDOGLAND

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 E20-E35
Name in latin Dysfunctio ovarialis

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 17415 17415 -
Only index persons 16983 16983 -
Unadjusted period prevalence (%)
Whole population 0.50 0.50 -
Only index persons 0.62 0.62 -
Median age at first event (years)
Whole population - 28.41 -
Only index persons - 28.30 -

-FinnGen-

Key figures

All Female Male
Number of individuals 2661 2661 -
Unadjusted period prevalence (%) 1.05 1.05 -
Median age at first event (years) 29.81 29.81 -

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

Association

Association between endpoint E4_OVARDYS and mortality.

Females

Parameter HR [95% CI] p-value
E4_OVARDYS 1.99 [1.65, 2.4] < 0.001
Birth year 0.995 [0.99, 1.0] 0.284

During the follow-up period (1.1.1998 — 31.12.2019), 243 out of 12980 females with E4_OVARDYS died.

Males

No data

Mortality risk

Mortality risk for people of age

years, who have E4_OVARDYS.

N-year risk Females Males
1 0.18% No data
5 1.088% No data
10 2.691% No data
15 5.534% No data
20 10.04% No data

Relationships between endpoints

Index endpoint: E4_OVARDYS – Ovarian dysfunction

GWS hits: 6

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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