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Polycystic ovarian syndrome

EFO Endpoint Browser PheWeb

E4_PCOS

Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

only females

265735

2. Check conditions

None

265735

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — E28.2
  • Hospital discharge: ICD-9 — 2564
  • Hospital discharge: ICD-8 — 25690
  • Cause of death: ICD-10 — E28.2
  • Cause of death: ICD-9 — 2564
  • Cause of death: ICD-8 — 25690

2 out of 7 registries used, show all original rules.

2035

4. Check minimum number of events

None

2035

5. Include endpoints

None

2035

6. Filter based on genotype QC (FinnGen only)

1909

Control definitions (FinnGen only)

Control exclude E4_ENDOGLAND

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF6
Parent code in ICD-10 E28
Name in latin Morbus polycysticus ovariorum

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 13242 13242 -
Only index persons 13074 13074 -
Unadjusted period prevalence (%)
Whole population 0.38 0.38 -
Only index persons 0.48 0.48 -
Median age at first event (years)
Whole population - 27.37 -
Only index persons - 27.35 -

-FinnGen-

Key figures

All Female Male
Number of individuals 1909 1909 -
Unadjusted period prevalence (%) 0.75 0.75 -
Median age at first event (years) 28.41 28.41 -

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Association

Association between endpoint E4_PCOS and mortality.

Females

Parameter HR [95% CI] p-value
E4_PCOS 1.36 [1.07, 1.73] 0.012
Birth year 0.992 [0.98, 1.0] 0.066

During the follow-up period (1.1.1998 — 31.12.2019), 104 out of 10334 females with E4_PCOS died.

Males

No data

Mortality risk

Mortality risk for people of age

years, who have E4_PCOS.

N-year risk Females Males
1 0.115% No data
5 0.624% No data
10 1.619% No data
15 3.275% No data
20 6.043% No data

Relationships between endpoints

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Index endpoint: E4_PCOS – Polycystic ovarian syndrome

GWS hits: 5

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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