No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
67 |
4. Check minimum number of eventsNone |
67 |
5. Include endpoints |
83 |
6. Filter based on genotype QC (FinnGen only) |
80 |
Control definitions (FinnGen only)
Control exclude
E4_ENDOGLAND
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
E20-E35
Name in latin
Morbi thymi
Similar endpoints
↥List of similar endpoints to
Diseases of thymus
based on the number of shared cases.
Similar with more cases:
- Disorders of other endocrine glands
- Endocrine, nutritional and metabolic diseases
- Any operation in hilmo
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 615 | 375 | 231 |
| Only index persons | 454 | 281 | 173 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.01 | 0.01 | 0.01 |
| Only index persons | 0.01 | 0.01 | 0.01 |
| Median age at first event (years) | |||
| Whole population | 57.22 | 60.39 | 51.51 |
| Only index persons | 49.79 | 52.25 | 45.80 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 80 | 48 | 32 |
| Unadjusted period prevalence (%) | 0.02 | 0.02 | 0.02 |
| Median age at first event (years) | 47.88 | 48.23 | 47.34 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
Mortality – FinRegistry
↥Association
Association between endpoint E4_THYMUSDIS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_THYMUSDIS | 2.212 [1.49, 3.28] | < 0.001 |
| Birth year | 0.991 [0.98, 1.0] | 0.041 |
During the follow-up period (1.1.1998 — 31.12.2019), 81 out of 234 females with E4_THYMUSDIS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_THYMUSDIS | 3.602 [1.75, 7.41] | < 0.001 |
| Birth year | 0.987 [0.98, 1.0] | 0.007 |
During the follow-up period (1.1.1998 — 31.12.2019), 54 out of 149 males with E4_THYMUSDIS died.
Mortality risk
Mortality risk for people of age
years, who have E4_THYMUSDIS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.18% | 0.795% |
| 5 | 1.148% | 4.018% |
| 10 | 2.685% | 9.576% |
| 15 | 5.111% | 17.15% |
| 20 | 9.273% | 29.089% |
Relationships between endpoints
↥Index endpoint: E4_THYMUSDIS – Diseases of thymus
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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