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Disease of thymus, other/unspecified

DOID Endpoint Browser PheWeb

E4_THYMUSDISNAS

Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — E32.8, E32.9
  • Hospital discharge: ICD-9 — 254[8-9]
  • Hospital discharge: ICD-8 — 25499
  • Cause of death: ICD-10 — E32.8, E32.9
  • Cause of death: ICD-9 — 254[8-9]
  • Cause of death: ICD-8 — 25499

2 out of 7 registries used, show all original rules.

52

4. Check minimum number of events

None

52

5. Include endpoints

None

52

6. Filter based on genotype QC (FinnGen only)

50

Control definitions (FinnGen only)

Control exclude E4_ENDOGLAND

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 334 201 131
Only index persons 276 163 113
Unadjusted period prevalence (%)
Whole population 0.00 0.01 0.00
Only index persons 0.01 0.01 0.00
Median age at first event (years)
Whole population 54.02 57.68 48.43
Only index persons 49.25 52.02 45.26

-FinnGen-

Key figures

All Female Male
Number of individuals 50 33 17
Unadjusted period prevalence (%) 0.01 0.01 0.01
Median age at first event (years) 47.58 45.40 51.80

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

No data

-FinnGen-

Cumulative Incidence Function

No data

Mortality – FinRegistry

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Association

Association between endpoint E4_THYMUSDISNAS and mortality.

Females

Parameter HR [95% CI] p-value
E4_THYMUSDISNAS 2.222 [1.27, 3.88] 0.005
Birth year 0.99 [0.98, 1.0] 0.02

During the follow-up period (1.1.1998 — 31.12.2019), 52 out of 136 females with E4_THYMUSDISNAS died.

Males

No data

Mortality risk

Mortality risk for people of age

years, who have E4_THYMUSDISNAS.

N-year risk Females Males
1 0.203% No data
5 1.219% No data
10 2.736% No data
15 5.372% No data
20 9.043% No data

Relationships between endpoints

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Index endpoint: E4_THYMUSDISNAS – Disease of thymus, other/unspecified

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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