hyperpituitarism: Disease of the glandular, anterior portion of the pituitary (pituitary gland, anterior) resulting in hypersecretion of adenohypophyseal hormones such as growth hormone; prolactin; thyrotropin; luteinizing hormone; follicle stimulating hormone ; and adrenocorticotropic hormone. Hyperpituitarism usually is caused by a functional adenoma.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
1662 |
4. Check minimum number of eventsNone |
1662 |
5. Include endpoints |
1832 |
6. Filter based on genotype QC (FinnGen only) |
1736 |
Control definitions (FinnGen only)
Control exclude
E4_ENDOGLAND
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
E20-E35
Name in latin
Hyperfunctio hypophysis
Similar endpoints
↥List of similar endpoints to
Hyperfunction of pituitary gland
based on the number of shared cases.
Similar with more cases:
- Disorders of other endocrine glands
- Endocrine, nutritional and metabolic diseases
- Any event in hilmo or specialist outpatient
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 13775 | 10007 | 3602 |
| Only index persons | 12382 | 9265 | 3117 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.24 | 0.29 | 0.10 |
| Only index persons | 0.28 | 0.34 | 0.12 |
| Median age at first event (years) | |||
| Whole population | 36.03 | 32.93 | 44.58 |
| Only index persons | 35.04 | 32.51 | 42.55 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 1736 | 1326 | 410 |
| Unadjusted period prevalence (%) | 0.45 | 0.52 | 0.21 |
| Median age at first event (years) | 38.04 | 34.33 | 50.03 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint E4_HYPERPIT and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_HYPERPIT | 1.864 [1.59, 2.18] | < 0.001 |
| Birth year | 0.996 [0.99, 1.0] | 0.314 |
During the follow-up period (1.1.1998 — 31.12.2019), 660 out of 7880 females with E4_HYPERPIT died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_HYPERPIT | 1.915 [1.63, 2.25] | < 0.001 |
| Birth year | 0.99 [0.98, 1.0] | 0.036 |
During the follow-up period (1.1.1998 — 31.12.2019), 521 out of 2276 males with E4_HYPERPIT died.
Mortality risk
Mortality risk for people of age
years, who have E4_HYPERPIT.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.217% | 0.38% |
| 5 | 1.083% | 2.337% |
| 10 | 2.632% | 6.055% |
| 15 | 5.096% | 10.909% |
| 20 | 9.329% | 18.171% |
Relationships between endpoints
↥Index endpoint: E4_HYPERPIT – Hyperfunction of pituitary gland
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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