inappropriate ADH syndrome: A syndrome characterized by abnormal secretion of antidiuretic hormone in conjunction with neoplastic growth occurring anywhere in the body.
Syndrome of inappropriate secretion of antidiuretic hormone
DOID EFO Endpoint Browser PheWeb
E4_ANTIDIU
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
157 |
4. Check minimum number of eventsNone |
157 |
5. Include endpointsNone |
157 |
6. Filter based on genotype QC (FinnGen only) |
149 |
Control definitions (FinnGen only)
Control exclude
E4_ENDOGLAND
Extra metadata
Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
E22
Name in latin
Syndroma secretionis impropriae hormonis antidiuretici
Similar endpoints
↥List of similar endpoints to
Syndrome of inappropriate secretion of antidiuretic hormone
based on the number of shared cases.
Similar with more cases:
- Hyperfunction of pituitary gland
- Exclusions for E4_PCOS_BROAD
- Disorders of other endocrine glands
- Endocrine, nutritional and metabolic diseases
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1631 | 971 | 648 |
| Only index persons | 1405 | 854 | 551 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.02 | 0.03 | 0.02 |
| Only index persons | 0.03 | 0.03 | 0.02 |
| Median age at first event (years) | |||
| Whole population | 71.56 | 74.37 | 67.48 |
| Only index persons | 72.04 | 74.92 | 67.57 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 149 | 76 | 73 |
| Unadjusted period prevalence (%) | 0.03 | 0.03 | 0.04 |
| Median age at first event (years) | 69.24 | 69.42 | 69.05 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
Mortality – FinRegistry
↥Association
Association between endpoint E4_ANTIDIU and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_ANTIDIU | 2.117 [1.65, 2.72] | < 0.001 |
| Birth year | 0.994 [0.98, 1.0] | 0.177 |
During the follow-up period (1.1.1998 — 31.12.2019), 348 out of 767 females with E4_ANTIDIU died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_ANTIDIU | 3.366 [2.32, 4.88] | < 0.001 |
| Birth year | 0.984 [0.97, 0.99] | 0.002 |
During the follow-up period (1.1.1998 — 31.12.2019), 270 out of 507 males with E4_ANTIDIU died.
Mortality risk
Mortality risk for people of age
years, who have E4_ANTIDIU.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.198% | 0.597% |
| 5 | 1.064% | 3.778% |
| 10 | 2.882% | 8.794% |
| 15 | 5.999% | 16.438% |
| 20 | 10.228% | 26.295% |
Relationships between endpoints
↥Index endpoint: E4_ANTIDIU – Syndrome of inappropriate secretion of antidiuretic hormone
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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