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Hyperprolactinaemia

DOID EFO Endpoint Browser PheWeb

E4_HYPERPRO

hyperprolactinemia: An acquired metabolic disease that has_material_basis_in the presence of abnormally-high levels of prolactin in the blood.

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Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — E22.1#
  • Hospital discharge: ICD-9 — 2531A
  • Cause of death: ICD-10 — E22.1#
  • Cause of death: ICD-9 — 2531A

2 out of 7 registries used, show all original rules.

1263

4. Check minimum number of events

None

1263

5. Include endpoints

None

1263

6. Filter based on genotype QC (FinnGen only)

1207

Control definitions (FinnGen only)

Control exclude E4_ENDOGLAND

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2
Parent code in ICD-10 E22
Name in latin Hyperprolactinaemia

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 7858 6346 1386
Only index persons 7530 6218 1312
Unadjusted period prevalence (%)
Whole population 0.16 0.18 0.04
Only index persons 0.20 0.23 0.05
Median age at first event (years)
Whole population 35.99 33.41 47.97
Only index persons 35.83 33.35 47.61

-FinnGen-

Key figures

All Female Male
Number of individuals 1207 1003 204
Unadjusted period prevalence (%) 0.34 0.39 0.10
Median age at first event (years) 36.80 34.06 50.27

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Association

Association between endpoint E4_HYPERPRO and mortality.

Females

Parameter HR [95% CI] p-value
E4_HYPERPRO 1.537 [1.32, 1.79] < 0.001
Birth year 0.995 [0.99, 1.0] 0.271

During the follow-up period (1.1.1998 — 31.12.2019), 228 out of 5615 females with E4_HYPERPRO died.

Males

Parameter HR [95% CI] p-value
E4_HYPERPRO 1.183 [1.0, 1.41] 0.056
Birth year 0.986 [0.98, 1.0] 0.005

During the follow-up period (1.1.1998 — 31.12.2019), 183 out of 1157 males with E4_HYPERPRO died.

Mortality risk

Mortality risk for people of age

years, who have E4_HYPERPRO.

N-year risk Females Males
1 0.122% 0.213%
5 0.784% 1.263%
10 2.184% 3.222%
15 4.019% 6.2%
20 7.392% 10.984%

Relationships between endpoints

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Index endpoint: E4_HYPERPRO – Hyperprolactinaemia

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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