hyperaldosteronism: Overproduction of aldosterone by the adrenal glands, which may lead to hypokalemia and/or hypernatremia. [ NCIT:P378 ]
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
360 |
4. Check minimum number of eventsNone |
360 |
5. Include endpointsNone |
360 |
6. Filter based on genotype QC (FinnGen only) |
344 |
Control definitions (FinnGen only)
Control exclude
E4_ENDOGLAND
Extra metadata
Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF6
Parent code in ICD-10
E20-E35
Name in latin
Syndroma Cushing
Similar endpoints
↥List of similar endpoints to
Cushing syndrome
based on the number of shared cases.
Similar with more cases:
- Disorders of other endocrine glands
- Endocrine, nutritional and metabolic diseases
- Any event in hilmo or specialist outpatient
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 2517 | 1702 | 780 |
| Only index persons | 1932 | 1354 | 578 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.04 | 0.05 | 0.02 |
| Only index persons | 0.04 | 0.05 | 0.02 |
| Median age at first event (years) | |||
| Whole population | 52.43 | 51.81 | 53.66 |
| Only index persons | 48.38 | 47.55 | 50.32 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 344 | 240 | 104 |
| Unadjusted period prevalence (%) | 0.08 | 0.09 | 0.05 |
| Median age at first event (years) | 50.27 | 46.37 | 59.26 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
Mortality – FinRegistry
↥Association
Association between endpoint E4_CUSHING and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_CUSHING | 3.602 [2.92, 4.44] | < 0.001 |
| Birth year | 0.996 [0.99, 1.0] | 0.334 |
During the follow-up period (1.1.1998 — 31.12.2019), 240 out of 978 females with E4_CUSHING died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_CUSHING | 3.754 [2.69, 5.23] | < 0.001 |
| Birth year | 0.986 [0.98, 1.0] | 0.003 |
During the follow-up period (1.1.1998 — 31.12.2019), 147 out of 409 males with E4_CUSHING died.
Mortality risk
Mortality risk for people of age
years, who have E4_CUSHING.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.26% | 0.602% |
| 5 | 2.009% | 4.136% |
| 10 | 5.011% | 10.054% |
| 15 | 9.495% | 19.573% |
| 20 | 16.424% | 30.551% |
Relationships between endpoints
↥Index endpoint: E4_CUSHING – Cushing syndrome
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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