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Disorders of pituitary gland, other and/or unspecified

DOID EFO Endpoint Browser PheWeb

E4_PITUDISNAS

Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — E23.6, E23.7
  • Hospital discharge: ICD-9 — 253[8-9]
  • Hospital discharge: ICD-8 — 2539
  • Hospital discharge: excluded ICD-8 — 25390
  • Cause of death: ICD-10 — E23.6, E23.7
  • Cause of death: ICD-9 — 253[8-9]
  • Cause of death: ICD-8 — 2539
  • Cause of death: excluded ICD-8 — 25390

2 out of 7 registries used, show all original rules.

182

4. Check minimum number of events

None

182

5. Include endpoints

None

182

6. Filter based on genotype QC (FinnGen only)

175

Control definitions (FinnGen only)

Control exclude E4_ENDOGLAND

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 1524 908 598
Only index persons 1235 751 484
Unadjusted period prevalence (%)
Whole population 0.02 0.03 0.02
Only index persons 0.02 0.03 0.02
Median age at first event (years)
Whole population 43.56 42.80 44.54
Only index persons 39.94 38.95 41.48

-FinnGen-

Key figures

All Female Male
Number of individuals 175 104 71
Unadjusted period prevalence (%) 0.04 0.04 0.04
Median age at first event (years) 42.54 40.07 46.15

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

Mortality – FinRegistry

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Association

Association between endpoint E4_PITUDISNAS and mortality.

Females

Parameter HR [95% CI] p-value
E4_PITUDISNAS 2.384 [1.81, 3.14] < 0.001
Birth year 0.992 [0.98, 1.0] 0.063

During the follow-up period (1.1.1998 — 31.12.2019), 84 out of 396 females with E4_PITUDISNAS died.

Males

Parameter HR [95% CI] p-value
E4_PITUDISNAS 1.387 [0.99, 1.95] 0.06
Birth year 0.989 [0.98, 1.0] 0.015

During the follow-up period (1.1.1998 — 31.12.2019), 55 out of 288 males with E4_PITUDISNAS died.

Mortality risk

Mortality risk for people of age

years, who have E4_PITUDISNAS.

N-year risk Females Males
1 0.202% 0.217%
5 1.248% 1.664%
10 3.13% 4.363%
15 5.77% 8.112%
20 10.357% 13.946%

Relationships between endpoints

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Index endpoint: E4_PITUDISNAS – Disorders of pituitary gland, other and/or unspecified

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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