No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
525 |
4. Check minimum number of eventsNone |
525 |
5. Include endpoints |
560 |
6. Filter based on genotype QC (FinnGen only) |
524 |
Control definitions (FinnGen only)
Control exclude
E4_ENDOGLAND
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
E20-E35
Name in latin
Perturbationes pubertatis non alibi classificatae
Similar endpoints
↥List of similar endpoints to
Disorders of puberty
based on the number of shared cases.
Similar with more cases:
- Disorders of puberty, all
- Disorders of other endocrine glands
- Endocrine, nutritional and metabolic diseases
- Any event in hilmo or specialist outpatient
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 13514 | 6222 | 7284 |
| Only index persons | 12248 | 5115 | 7133 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.19 | 0.18 | 0.20 |
| Only index persons | 0.24 | 0.19 | 0.27 |
| Median age at first event (years) | |||
| Whole population | 12.30 | 9.31 | 14.85 |
| Only index persons | 12.72 | 9.74 | 14.86 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 524 | 322 | 202 |
| Unadjusted period prevalence (%) | 0.12 | 0.13 | 0.10 |
| Median age at first event (years) | 12.91 | 11.63 | 14.95 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
Mortality – FinRegistry
↥Association
Association between endpoint E4_DISPUB and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_DISPUB | 2.342 [1.77, 3.1] | < 0.001 |
| Birth year | 0.993 [0.98, 1.0] | 0.105 |
During the follow-up period (1.1.1998 — 31.12.2019), 167 out of 5264 females with E4_DISPUB died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_DISPUB | 2.384 [1.66, 3.42] | < 0.001 |
| Birth year | 0.985 [0.98, 0.99] | 0.002 |
During the follow-up period (1.1.1998 — 31.12.2019), 143 out of 6399 males with E4_DISPUB died.
Mortality risk
Mortality risk for people of age
years, who have E4_DISPUB.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.252% | 0.451% |
| 5 | 1.399% | 2.825% |
| 10 | 3.368% | 6.764% |
| 15 | 6.23% | 12.543% |
| 20 | 10.628% | 20.128% |
Relationships between endpoints
↥Index endpoint: E4_DISPUB – Disorders of puberty
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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