No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
293 |
4. Check minimum number of eventsNone |
293 |
5. Include endpointsNone |
293 |
6. Filter based on genotype QC (FinnGen only) |
282 |
Control definitions (FinnGen only)
Control exclude
E4_ENDOGLAND
Extra metadata
Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Similar endpoints
↥List of similar endpoints to
Delayed puberty
based on the number of shared cases.
Similar with more cases:
- Disorders of puberty
- Disorders of puberty, all
- Disorders of other endocrine glands
- Endocrine, nutritional and metabolic diseases
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 7828 | 1705 | 6119 |
| Only index persons | 7752 | 1673 | 6079 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.14 | 0.05 | 0.17 |
| Only index persons | 0.20 | 0.06 | 0.23 |
| Median age at first event (years) | |||
| Whole population | 14.73 | 13.87 | 14.97 |
| Only index persons | 14.73 | 13.86 | 14.96 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 282 | 121 | 161 |
| Unadjusted period prevalence (%) | 0.07 | 0.05 | 0.08 |
| Median age at first event (years) | 14.74 | 14.39 | 15.00 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
Mortality – FinRegistry
↥Association
Association between endpoint E4_DELPUB and mortality.
Females
No dataMales
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_DELPUB | 1.963 [1.44, 2.68] | < 0.001 |
| Birth year | 0.985 [0.98, 1.0] | 0.003 |
During the follow-up period (1.1.1998 — 31.12.2019), 74 out of 5417 males with E4_DELPUB died.
Mortality risk
Mortality risk for people of age
years, who have E4_DELPUB.| N-year risk | Females | Males |
|---|---|---|
| 1 | No data | 0.338% |
| 5 | No data | 2.166% |
| 10 | No data | 5.179% |
| 15 | No data | 10.013% |
| 20 | No data | 16.731% |
Relationships between endpoints
↥Index endpoint: E4_DELPUB – Delayed puberty
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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