No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
133 |
4. Check minimum number of eventsNone |
133 |
5. Include endpointsNone |
133 |
6. Filter based on genotype QC (FinnGen only) |
124 |
Control definitions (FinnGen only)
Control exclude
E4_ENDOGLAND
Extra metadata
Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Similar endpoints
↥List of similar endpoints to
Disorders of puberty, other/unspecified
based on the number of shared cases.
Similar with more cases:
- Disorders of puberty
- Disorders of puberty, all
- Disorders of other endocrine glands
- Endocrine, nutritional and metabolic diseases
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 2778 | 2033 | 744 |
| Only index persons | 2125 | 1439 | 686 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.05 | 0.06 | 0.02 |
| Only index persons | 0.04 | 0.05 | 0.03 |
| Median age at first event (years) | |||
| Whole population | 9.61 | 7.65 | 14.97 |
| Only index persons | 10.35 | 8.12 | 15.01 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 124 | 93 | 31 |
| Unadjusted period prevalence (%) | 0.03 | 0.04 | 0.02 |
| Median age at first event (years) | 11.23 | 9.83 | 15.44 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
Mortality – FinRegistry
↥Association
Association between endpoint E4_PUBDISNAS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_PUBDISNAS | 2.209 [1.53, 3.18] | < 0.001 |
| Birth year | 0.992 [0.98, 1.0] | 0.079 |
During the follow-up period (1.1.1998 — 31.12.2019), 97 out of 1798 females with E4_PUBDISNAS died.
Males
No dataMortality risk
Mortality risk for people of age
years, who have E4_PUBDISNAS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.179% | No data |
| 5 | 1.09% | No data |
| 10 | 2.848% | No data |
| 15 | 5.741% | No data |
| 20 | 9.391% | No data |
Relationships between endpoints
↥Index endpoint: E4_PUBDISNAS – Disorders of puberty, other/unspecified
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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