hyperaldosteronism: Overproduction of aldosterone by the adrenal glands, which may lead to hypokalemia and/or hypernatremia. [ NCIT:P378 ]
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
859 |
4. Check minimum number of eventsNone |
859 |
5. Include endpointsNone |
859 |
6. Filter based on genotype QC (FinnGen only) |
823 |
Control definitions (FinnGen only)
Control exclude
E4_ENDOGLAND
Extra metadata
Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
E20-E35
Name in latin
Hyperaldosteronismus
Similar endpoints
↥List of similar endpoints to
Hyperaldosteronism
based on the number of shared cases.
Similar with more cases:
- Disorders of other endocrine glands
- Endocrine, nutritional and metabolic diseases
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 5523 | 2949 | 2543 |
| Only index persons | 5035 | 2705 | 2330 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.08 | 0.08 | 0.07 |
| Only index persons | 0.09 | 0.10 | 0.09 |
| Median age at first event (years) | |||
| Whole population | 57.31 | 56.48 | 58.24 |
| Only index persons | 56.72 | 55.67 | 57.95 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 823 | 449 | 374 |
| Unadjusted period prevalence (%) | 0.18 | 0.18 | 0.19 |
| Median age at first event (years) | 56.95 | 54.73 | 59.62 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint E4_HYPERALDO and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_HYPERALDO | 1.424 [1.23, 1.65] | < 0.001 |
| Birth year | 0.993 [0.98, 1.0] | 0.123 |
During the follow-up period (1.1.1998 — 31.12.2019), 414 out of 2277 females with E4_HYPERALDO died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_HYPERALDO | 1.218 [1.05, 1.41] | 0.009 |
| Birth year | 0.985 [0.98, 0.99] | 0.002 |
During the follow-up period (1.1.1998 — 31.12.2019), 357 out of 2005 males with E4_HYPERALDO died.
Mortality risk
Mortality risk for people of age
years, who have E4_HYPERALDO.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.081% | 0.205% |
| 5 | 0.68% | 1.319% |
| 10 | 2.096% | 3.219% |
| 15 | 3.905% | 6.3% |
| 20 | 7.079% | 10.338% |
Relationships between endpoints
↥Index endpoint: E4_HYPERALDO – Hyperaldosteronism
GWS hits: 2
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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