≡ Risteys
FG R11 + FR

Documentation Changelog GitHub Contact & Feedback

Diabetes insipidus

DOID EFO Endpoint Browser PheWeb

E4_DIABINSIPIDUS

Endpoint definition

↥

Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — E23.2
  • Hospital discharge: ICD-9 — 2535
  • Hospital discharge: ICD-8 — 25390
  • Cause of death: ICD-10 — E23.2
  • Cause of death: ICD-9 — 2535
  • Cause of death: ICD-8 — 25390

2 out of 7 registries used, show all original rules.

288

4. Check minimum number of events

None

288

5. Include endpoints

None

288

6. Filter based on genotype QC (FinnGen only)

278

Control definitions (FinnGen only)

Control exclude E4_ENDOGLAND

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2
Parent code in ICD-10 E23
Name in latin Diabetes insipidus

Case counts by codes

↥

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 1936 1022 905
Only index persons 1614 884 730
Unadjusted period prevalence (%)
Whole population 0.03 0.03 0.03
Only index persons 0.03 0.03 0.03
Median age at first event (years)
Whole population 43.88 45.33 42.11
Only index persons 42.57 44.24 40.55

-FinnGen-

Key figures

All Female Male
Number of individuals 278 171 107
Unadjusted period prevalence (%) 0.06 0.07 0.05
Median age at first event (years) 46.20 45.67 47.05

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

Mortality – FinRegistry

↥

Association

Association between endpoint E4_DIABINSIPIDUS and mortality.

Females

Parameter HR [95% CI] p-value
E4_DIABINSIPIDUS 3.239 [2.46, 4.27] < 0.001
Birth year 1.001 [0.99, 1.01] 0.864

During the follow-up period (1.1.1998 — 31.12.2019), 127 out of 716 females with E4_DIABINSIPIDUS died.

Males

Parameter HR [95% CI] p-value
E4_DIABINSIPIDUS 2.412 [1.78, 3.27] < 0.001
Birth year 0.988 [0.98, 1.0] 0.015

During the follow-up period (1.1.1998 — 31.12.2019), 120 out of 595 males with E4_DIABINSIPIDUS died.

Mortality risk

Mortality risk for people of age

years, who have E4_DIABINSIPIDUS.

N-year risk Females Males
1 0.39% 0.489%
5 2.107% 3.104%
10 5.629% 7.422%
15 10.58% 13.857%
20 18.654% 22.663%

Relationships between endpoints

↥

Index endpoint: E4_DIABINSIPIDUS – Diabetes insipidus

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
loading spinner Loading data