heart disease: A disease involving the heart and/or pericardium.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersNone 0 out of 7 registries used, show all original rules. |
0 |
4. Check minimum number of eventsNone |
0 |
5. Include endpoints |
97463 |
6. Filter based on genotype QC (FinnGen only) |
94162 |
Control definitions (FinnGen only)
Control exclude
FG_CVD
Extra metadata
Level in the ICD hierarchy
C
First used in FinnGen datafreeze
DF2
Other heart diseases
based on the number of shared cases.
Similar with more cases:
Similar with less cases:
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1056812 | 512590 | 531145 |
| Only index persons | 767895 | 377527 | 390368 |
| Unadjusted period prevalence (%) | |||
| Whole population | 14.75 | 14.68 | 14.84 |
| Only index persons | 14.40 | 13.88 | 14.90 |
| Median age at first event (years) | |||
| Whole population | 69.39 | 72.33 | 66.55 |
| Only index persons | 68.81 | 72.06 | 65.67 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 94162 | 38821 | 55341 |
| Unadjusted period prevalence (%) | 22.62 | 15.25 | 27.79 |
| Median age at first event (years) | 66.33 | 66.18 | 66.44 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint FG_OTHHEART and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| FG_OTHHEART | 1.826 [1.7, 1.97] | < 0.001 |
| Birth year | 0.987 [0.98, 0.99] | < 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 137788 out of 330645 females with FG_OTHHEART died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| FG_OTHHEART | 1.948 [1.8, 2.11] | < 0.001 |
| Birth year | 0.978 [0.97, 0.99] | < 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 132308 out of 340285 males with FG_OTHHEART died.
Mortality risk
Mortality risk for people of age
years, who have FG_OTHHEART.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.094% | 0.208% |
| 5 | 0.628% | 1.218% |
| 10 | 1.537% | 2.882% |
| 15 | 2.869% | 5.374% |
| 20 | 4.867% | 8.821% |
Relationships between endpoints
↥Index endpoint: FG_OTHHEART – Other heart diseases
GWS hits: 54
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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