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Endocarditis

DOID EFO Endpoint Browser PheWeb

I9_ENDOCARD

Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — I33, I38, I39*
  • Hospital discharge: ICD-9 — 421|4249|0932A
  • Hospital discharge: ICD-8 — 421
  • Cause of death: ICD-10 — I33, I38, I39*
  • Cause of death: ICD-9 — 421|4249|0932A
  • Cause of death: ICD-8 — 421

2 out of 7 registries used, show all original rules.

1194

4. Check minimum number of events

None

1194

5. Include endpoints

None

1194

6. Filter based on genotype QC (FinnGen only)

1140

Control definitions (FinnGen only)

Control exclude I9_OTHHEART

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF6

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 11617 4095 7361
Only index persons 8098 2778 5320
Unadjusted period prevalence (%)
Whole population 0.17 0.12 0.21
Only index persons 0.17 0.10 0.20
Median age at first event (years)
Whole population 63.81 67.80 61.53
Only index persons 61.72 64.49 60.28

-FinnGen-

Key figures

All Female Male
Number of individuals 1140 337 803
Unadjusted period prevalence (%) 0.32 0.13 0.40
Median age at first event (years) 63.19 60.60 64.28

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Association

Association between endpoint I9_ENDOCARD and mortality.

Females

Parameter HR [95% CI] p-value
I9_ENDOCARD 3.233 [2.73, 3.82] < 0.001
Birth year 0.995 [0.99, 1.0] 0.262

During the follow-up period (1.1.1998 — 31.12.2019), 1079 out of 2258 females with I9_ENDOCARD died.

Males

Parameter HR [95% CI] p-value
I9_ENDOCARD 2.642 [2.3, 3.03] < 0.001
Birth year 0.987 [0.98, 1.0] 0.007

During the follow-up period (1.1.1998 — 31.12.2019), 1780 out of 4294 males with I9_ENDOCARD died.

Mortality risk

Mortality risk for people of age

years, who have I9_ENDOCARD.

N-year risk Females Males
1 0.296% 0.476%
5 1.536% 3.215%
10 4.302% 7.882%
15 9.026% 14.271%
20 15.834% 23.785%

Relationships between endpoints

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Index endpoint: I9_ENDOCARD – Endocarditis

GWS hits: 1

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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